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- ½ð±Ò: 2754.6
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- ÐÔ±ð: MM
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2Â¥2010-05-30 20:36:13
lz3333
ÖÁ×ðľ³æ (ÕýʽдÊÖ)
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wypward(½ð±Ò+1):лл²ÎÓë 2010-05-30 22:42:48
xhyhnsfdx(½ð±Ò+1): 2010-05-31 12:09:35
wypward(½ð±Ò+1):лл²ÎÓë 2010-05-30 22:42:48
xhyhnsfdx(½ð±Ò+1): 2010-05-31 12:09:35
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Ï£ÍûÓÐËù°ïÖú This specificity of the binding pocket is half polar and half neutral according to the surface charge property. ÒÀÕÕ±íÃæµçºÉÐÔÖÊ,Õâ¸ö½áºÏ´üµÄÌØÒìÐÔÊǰ뼫ÐÔ°ëÖÐÐԵġ£ The compounds were initially docked into the binding pocket of the homology model of 5-HT3 receptor using GOLD program. ʹÓÃGOLDÈí¼þ½«´ËÀ໯ºÏÎï¶Ô½Óµ½Í¬Ô´Ä£½¨µÄ5-HT3ÊÜÌåµÄ½áºÏÖÐÐÄ£¬½«µÃ·Ö×î¸ßµÄ¹¹Ïóµ¼³öÓÃÓÚÄ£Ð͵Ľ¨Á¢¡£ The environment of nucleotide-binding pocket and Structural change of ras P21 upon GTP hydrolysis are discussed. ¶Ôras P21ºËÜÕËá½áºÏ¿Ú´üµÄ΢»·¾³ºÍras P21ÔÚCTPË®½â¹ý³ÌÖеĽṹ±ä»¯½øÐÐÁËÌÖÂÛ¡£ |
3Â¥2010-05-30 21:41:19
xhyhnsfdx(½ð±Ò+1): 2010-05-31 12:10:57
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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. ¼×Á×ËáË¿°±Ëá/ËÕ°±Ëá½áºÏ´üµÄ×Ô¶¯ÔöÒæ¿ØÖƺÍPDK1¼¤Ã¸½éµ¼¼¤»îµÄÊèË®»ùÁ×Ëữ¡£ Nociceptin fits well into the binding pocket, the N-terminal PGGF tetrapep-tide is located in the inner region of the binding cavity, the nociceptin (5 - 7) interacts with the conservatively variable residues near the other end of binding pocket, and maybe determines selectivity of ORL1 receptor over dynorphin A, the positively charged core of nociceptin (8-13) binds predominantly with negatively charged EL-2 loop, which is thought to be able to mediate receptor activation. ¹Â·ÈëÄ(1-4)²Ð»ùλÓÚ½áºÏ¿Ú´üµÄµ×²¿,¹Â·ÈëÄ(5-7)²Ð»ùλÓÚ½áºÏ¿Ú´üµÄ¶¥²¿,¹Â·ÈëÄ(8-17)²Ð»ùÓë¹Â¶ùÊÜÌåµÄµÚ¶þĤÍâ»·Çø½áºÏ; ×ÛÉÏ£¬ºÃÌýµã¾Í½Ð½áºÏ´ü |
4Â¥2010-05-31 08:48:49
xhyhnsfdx
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5Â¥2010-05-31 12:10:20
lppv
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- ×¢²á: 2010-01-05
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6Â¥2010-05-31 16:15:47













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