²é¿´: 3099  |  »Ø¸´: 5
±¾Ìû²úÉú 1 ¸ö ·­ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴

xhyhnsfdx

½ð³æ (СÓÐÃûÆø)

[½»Á÷] binding pocketÇóÖú·­Òë°¡

Çë½Ì£¬Õâ¸öbinding pocketÔÚÓлúÎÄÏ×ÉÏÃæÔõô·­ÒëºÏÊʰ¡

» ²ÂÄãϲ»¶

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

sdywhxlql

½ð³æ (СÓÐÃûÆø)

xhyhnsfdx(½ð±Ò+1, ·­ÒëEPI+1): 2010-05-31 12:08:01
ûÓÐÉÏÏÂÎÄ£¬²»ÖªµÀ½áºÏÇø¿É²»¿ÉÒÔ
2Â¥2010-05-30 20:36:13
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

lz3333

ÖÁ×ðľ³æ (ÕýʽдÊÖ)

¡ï
wypward(½ð±Ò+1):лл²ÎÓë 2010-05-30 22:42:48
xhyhnsfdx(½ð±Ò+1): 2010-05-31 12:09:35
Ï£ÍûÓÐËù°ïÖú
This specificity of the binding pocket is half polar and half neutral according to the surface charge property.
ÒÀÕÕ±íÃæµçºÉÐÔÖÊ,Õâ¸ö½áºÏ´üµÄÌØÒìÐÔÊǰ뼫ÐÔ°ëÖÐÐԵġ£

The compounds were initially docked into the binding pocket of the homology model of 5-HT3 receptor using GOLD program.
ʹÓÃGOLDÈí¼þ½«´ËÀ໯ºÏÎï¶Ô½Óµ½Í¬Ô´Ä£½¨µÄ5-HT3ÊÜÌåµÄ½áºÏÖÐÐÄ£¬½«µÃ·Ö×î¸ßµÄ¹¹Ïóµ¼³öÓÃÓÚÄ£Ð͵Ľ¨Á¢¡£
The environment of nucleotide-binding pocket and Structural change of ras P21 upon GTP hydrolysis are discussed.
¶Ôras P21ºËÜÕËá½áºÏ¿Ú´üµÄ΢»·¾³ºÍras P21ÔÚCTPË®½â¹ý³ÌÖеĽṹ±ä»¯½øÐÐÁËÌÖÂÛ¡£
3Â¥2010-05-30 21:41:19
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

Bahamut_517

xhyhnsfdx(½ð±Ò+1): 2010-05-31 12:10:57
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
¼×Á×ËáË¿°±Ëá/ËÕ°±Ëá½áºÏ´üµÄ×Ô¶¯ÔöÒæ¿ØÖƺÍPDK1¼¤Ã¸½éµ¼¼¤»îµÄÊèË®»ùÁ×Ëữ¡£


Nociceptin fits well into the binding pocket, the N-terminal PGGF tetrapep-tide is located in the inner region of the binding cavity, the nociceptin (5 - 7) interacts with the conservatively variable residues near the other end of binding pocket, and maybe determines selectivity of ORL1 receptor over dynorphin A, the positively charged core of nociceptin (8-13) binds predominantly with negatively charged EL-2 loop, which is thought to be able to mediate receptor activation.

¹Â·ÈëÄ(1-4)²Ð»ùλÓÚ½áºÏ¿Ú´üµÄµ×²¿,¹Â·ÈëÄ(5-7)²Ð»ùλÓÚ½áºÏ¿Ú´üµÄ¶¥²¿,¹Â·ÈëÄ(8-17)²Ð»ùÓë¹Â¶ùÊÜÌåµÄµÚ¶þĤÍâ»·Çø½áºÏ;


×ÛÉÏ£¬ºÃÌýµã¾Í½Ð½áºÏ´ü
4Â¥2010-05-31 08:48:49
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

xhyhnsfdx

½ð³æ (СÓÐÃûÆø)

лл¸÷λÁ˰¡
5Â¥2010-05-31 12:10:20
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

lppv

ÈÙÓþ°æÖ÷ (ÎÄ̳¾«Ó¢)

ÎÞÓëÂױȾãÀÖ²¿²¿³¤

ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷

xhyhnsfdx(½ð±Ò+2): 2010-06-02 10:54:49
¶þ¥˵ÊǽáºÏÇø£¬

½áºÏλµã ÊDz»ÊǸü׼ȷ¡¢¸ü×¨ÒµÄØ¡£
½áºÏ´ü²»Ì«ºÃÌýÂï¡£¡£¡£

[ Last edited by lppv on 2010-5-31 at 16:18 ]
ÈË»îןÃûÒâ˼°¡
6Â¥2010-05-31 16:15:47
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ xhyhnsfdx µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ²ÄÁϹ¤³Ìר˶µ÷¼Á +5 204818@lcx 2026-03-17 6/300 2026-03-18 22:55 by 204818@lcx
[¿¼ÑÐ] 085700×ÊÔ´Óë»·¾³308Çóµ÷¼Á +3 īīĮ 2026-03-18 3/150 2026-03-18 22:35 by bingxueer79
[¿¼ÑÐ] Çó²ÄÁϵ÷¼Á +8 ¸ô±Ú³ÂÏÈÉú 2026-03-12 8/400 2026-03-18 22:19 by li123456789.
[¿¼ÑÐ] 267Ò»Ö¾Ô¸ÄϾ©¹¤Òµ´óѧ0817»¯¹¤Çóµ÷¼Á +8 SUICHILD 2026-03-12 8/400 2026-03-18 20:55 by winsuccess
[½Ìʦ֮¼Ò] ½¹ÂÇ +8 Ë®±ùÔÂÔÂÒ°Íà 2026-03-13 12/600 2026-03-18 15:27 by ßäÎØß÷ÎØ
[¿¼ÑÐ] 331Çóµ÷¼Á£¨0703Óлú»¯Ñ§ +7 ZY-05 2026-03-13 8/400 2026-03-18 14:13 by 007_lilei
[¿¼ÑÐ] 299Çóµ÷¼Á +5 ¡÷С͸Ã÷* 2026-03-17 5/250 2026-03-18 11:49 by ¾¡Ë´Ò¢1
[¿¼ÑÐ] 334Çóµ÷¼Á +3 Ö¾´æ¸ßÔ¶ÒâÔÚ»úÐ 2026-03-16 3/150 2026-03-18 08:34 by lm4875102
[¿¼ÑÐ] ²ÄÁÏר˶326Çóµ÷¼Á +6 Ä«ìÏæ¦Ý· 2026-03-15 7/350 2026-03-17 17:10 by ruiyingmiao
[¿¼ÑÐ] 290Çóµ÷¼Á +3 p asserby. 2026-03-15 4/200 2026-03-17 16:35 by wangkm
[¿¼ÑÐ] 11408 Ò»Ö¾Ô¸Î÷µç£¬277·ÖÇóµ÷¼Á +3 zhouzhen654 2026-03-16 3/150 2026-03-17 07:03 by laoshidan
[»ù½ðÉêÇë] ¹ú×Ô¿ÆÃæÉÏ»ù½ð×ÖÌå +6 iwuli 2026-03-12 7/350 2026-03-16 21:18 by sculhf
[¿¼ÑÐ] 333Çóµ÷¼Á +3 ÎÄ˼¿Í 2026-03-16 7/350 2026-03-16 18:21 by ÎÄ˼¿Í
[¿¼ÑÐ] 0703 ÎïÀí»¯Ñ§µ÷¼Á +3 ÎÒ¿ÉÒÔÉϰ¶µÄ¶Ô 2026-03-13 5/250 2026-03-16 10:50 by ÎÒ¿ÉÒÔÉϰ¶µÄ¶ÔÂ
[¿¼ÑÐ] 0856Çóµ÷¼Á +3 ÁõÃÎ΢ 2026-03-15 3/150 2026-03-16 10:00 by houyaoxu
[¿¼ÑÐ] ¸´ÊÔµ÷¼Á +3 ºôºô£¿~+123456 2026-03-14 3/150 2026-03-14 16:53 by WTUChen
[¿¼ÑÐ] ²ÄÁÏ080500µ÷¼ÁÇóÊÕÁô +3 Ò»¿Åmeteor 2026-03-13 3/150 2026-03-14 10:54 by peike
[¿¼ÑÐ] 304Çóµ÷¼Á +7 7712b 2026-03-13 7/350 2026-03-13 21:42 by peike
[¿¼ÑÐ] 0703»¯Ñ§Çóµ÷¼Á +7 Â̶¹ÇÛ²ËÌÀ 2026-03-12 7/350 2026-03-13 17:25 by njzyff
[¿¼ÑÐ] 328»¯¹¤×¨Ë¶Çóµ÷¼Á +4 ¡££¬¡££¬¡££¬¡£i 2026-03-12 4/200 2026-03-13 14:44 by JourneyLucky
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û