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求两篇SCI检索号，每篇3金币
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1. Linhua Liu,Yiguo Jiang, Hongyu Zhang, Anne R. Greenlee, Rian Yu and Qiaoyuan Yang. MiR-22 functions as a micro-oncogene in transformed human bronchial epithelial cells induced by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide.Toxicology in vitro.2010; PMID: 20170724 2. Linhua Liu,Yiguo Jiang,Hongyu Zhang,Anne R.Greenlee and Zhiyuan Han.Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide.Life Sciences.2010;86(5-6):192-198. 多谢！ |
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hzwhut
版主 (著名写手)
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第二篇的信息
★
lhliu2087(金币+1):谢谢参与
lhliu2087(金币+1):谢谢参与
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作者: Liu LH (Liu, Linhua)1, Jiang YG (Jiang, Yiguo)1, Zhang HY (Zhang, Hongyu)3, Greenlee AR (Greenlee, Anne R.)2, Han ZY (Han, Zhiyuan)1 来源出版物: LIFE SCIENCES 卷: 86 期: 5-6 页: 192-198 出版年: JAN 30 2010 被引频次: 0 参考文献: 38 引证关系图 摘要: Aims: We investigated the functionality of miR-494 in anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (anti-BPDE)-transformed human bronchial epithelial cell 16HBE to reveal its potential target coding-gene. Main methods: The expression of mature miR-494 in cells was detected by miRNA-specific quantitative real-time polymerase chain reaction (QRT-PCR). QRT-PCR and Western blot were used to identify the expression of phosphatase and tensin homolog (PTEN) mRNA and protein. Following activation or inhibition of mature miRNA expression with precursors or antisense inhibitors, PTEN expression, luciferase activities, cell apoptosis, cell growth in soft agar and cell motility were analyzed. Key findings: The expression of miR-494 increased while PTEN protein appeared to be lower in malignant transformed 16HBE cells. Enforced miR-494 level decreased PTEN protein expression compared to a negative precursor control group. Inhibition of miR-494 expression increased PTEN protein expression compared to negative inhibitor control group. Decreased expression of miR-494 increased caspase-3/7 activities in transformed 16HBE cells, and increased expression of miR-494 decreased this activity. Inhibition of miR-494 also decreased the malignancy of transformed cells. Significance: MiR-494 regulates the expression of PTEN post-transcriptionally and functions as a micro-oncogene in carcinogenesis induced by anti-BPDE. MiR-494 may be a useful target for gene therapy. (C) 2009 Elsevier Inc. All rights reserved. 文献类型: Article 语言: English 作者关键词: Anti-BPDE; Cell transformation; MicroRNA; MiR-494; PTEN KeyWords Plus: LUNG-CANCER CELLS; MICRORNA EXPRESSION; PHOSPHORYLATED AKT; GROWTH; PROGNOSIS; CARCINOMA; APOPTOSIS; PROFILES; MIR-21; MIRNAS 通讯作者地址: Jiang, YG (通讯作者), Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, 195 Dongfengxi Rd, Guangzhou 510182, Guangdong Peoples R China 地址: 1. Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong Peoples R China 2. Jackson Lab, Stem Cell & Primary Cell Facil, Bar Harbor, ME 04609 USA 3. Sun Yat Sen Univ, Dept Med Oncol, Affiliated Hosp 1, Zhuhai 519000, Peoples R China 电子邮件地址: jiangyiguo@yahoo.com 基金资助致谢: 基金资助机构 授权号 National Natural Science Foundation of China 30571546 30771780 Scientific Research Foundation of the State Education Ministry for Returned Overseas Chinese Scholars 2007-24 Natural Science Foundation of Guangdong Province 07117550 9251018201000004 Natural Science Key Program of Higher Education Institutions of Guangdong Province, China 06Z021 Science and Technology Program of Guangzhou Bureau of Education, China 08A093 [显示基金资助信息] This work was supported by the National Natural Science Foundation of China (30571546, 30771780), the Scientific Research Foundation of the State Education Ministry for Returned Overseas Chinese Scholars (2007-24), the Natural Science Foundation of Guangdong Province (07117550, 9251018201000004), the Natural Science Key Program of Higher Education Institutions of Guangdong Province, China (06Z021) and the Science and Technology Program of Guangzhou Bureau of Education, China (08A093). 出版商: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND IDS 号: 552UC ISSN: 0024-3205 DOI: 10.1016/j.lfs.2009.12.002 |
2楼2010-03-03 17:34:12
hzwhut
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3楼2010-03-03 17:44:51