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【求助】扎那米韦的分析
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哪位虫友做过扎那米韦这种药物分析的请不吝赐教!!! 主要包括以下两个方面:比旋度,HPLC分析中可能存在的杂质.谢谢. [ Last edited by 笨笨猪0608 on 2009-9-30 at 08:10 ] |
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zmkj
木虫 (正式写手)
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扎那米韦
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Title: Zanamivir CAS Registry Number: 139110-80-8 CAS Name: 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid Additional Names: 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid; 4-guanidino-Neu5Ac2en; 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid Manufacturers' Codes: GG-167; GR-121167X Trademarks: Relenza (GSK) Molecular Formula: C12H20N4O7 Molecular Weight: 332.31 Percent Composition: C 43.37%, H 6.07%, N 16.86%, O 33.70% Literature References: Influenza viral neuraminidase inhibitor; structural analog of the sialic acids, q.v. Prepn: L. M. von Itzstein et al., WO 9116320; eidem, US 5360817 (1991, 1994 both to Biota); M. von Itzstein et al., Carbohydr. Res. 259, 301 (1994). Structure-activity study: eidem et al., Nature 363, 418 (1993). Inhibition of sialidase (neuraminidase) from influenza virus: M. S. Pegg, M. von Itzstein, Biochem. Mol. Biol. Int. 32, 851 (1994). In vitro antiviral activity: J. M. Woods et al., Antimicrob. Agents Chemother. 37, 1473 (1993). HPLC determn in serum: R. J. Stubbs, A. J. Harker, J. Chromatogr. B 670, 279 (1995). Clinical trial in influenza A and B infection: F. G. Hayden et al., N. Engl. J. Med. 337, 874 (1997); in prevention of influenza in healthy adults: A. S. Monto et al., J. Am. Med. Assoc. 282, 31 (1999). Properties: Colorless crystals as the sesquihydrate, mp 256° (dec). [a]D20 +40.9° (c = 0.9 in water). Zwitterionic at physiological pH. Melting point: mp 256° (dec) Optical Rotation: [a]D20 +40.9° (c = 0.9 in water) Therap-Cat: Antiviral. Keywords: Antiviral; Sialic Acid Analogs; Neuraminidase Inhibitor. |
7楼2009-12-08 15:53:08
montclimber
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2楼2009-10-03 20:43:09
zqwxling
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3楼2009-10-04 08:20:54
zhongweixu
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4楼2009-10-10 15:20:59
