[交流] CSC PhD student from 2022 for project on 3D human muscle tissue engineering

the research environment. university of copenhagen, department of nutrition, exercise and sports (nexs) is currently ranked #1 on shanghai ranking among academic exercise and sports institutions worldwide. https://nexs.ku.dk/english/ within nexs, the august krogh section of molecular physiology′s research output is a major contributor to this success, being the most productive in terms of scientific productivity, impact-metrics and funding-acquisition. https://nexs.ku.dk/english/research/molecular-physiology/ in the section of molecular physiology, associate professor thomas e. jensen (tej) is the youngest of four 4 permanently employed pis, the others being professors erik a. richter, bente kiens and jørgen wojtaszewski, all well-recognized capacities within human molecular exercise metabolism research. in total, the section comprises at any given time an international mix of 30-40 phds, post docs, visiting scientists, and 4 shared lab technicians + 5-10 master students. tej heads one of 3 research groups within the section “muscle growth and metabolism” focusing on the study of signal transduction mechanisms in healthy and unhealthy skeletal muscle in models ranging from cell culture to mice to human biopsies. his group currently comprises 4 post doc and 2 phd students. tej has supervised two csc phd students previously, both of which successfully completed their projects. references from former csc students can be provided upon request. the project in brief. currently there is no means of generating and culturing metabolically mature human skeletal muscle tissue in vitro, which would be a game-changer in human muscle physiology research. however, emerging techniques for engineering 3d in vitro models of human tissue is a rapidly developing and hold the potential to generate metabolically mature human muscle tissue. we are currently developing a human pluripotent stem cell based 3d multi-material printing approach to generate human muscle tissue. the current project involves biochemically characterizing metabolic and contractile maturity of this tissue model as well as translating already established endpoints including glucose transporter translocation, insulin sensitivity, force development and hypertrophy to this model. finally, robust aav induction in the tissue needs to be established.   upon successful characterization of the human muscle tissue, this model will be applied to answer metabolic questions relating to skeletal muscle disease development as well as be developed as a drug screening tool in collaboration with an industry partner.    your profile. the candidate should have a degree in biology, biochemistry, medicine or similar, preferably with a strong background in and understanding of molecular cell biology, biochemistry and metabolism. prior laboratory work experience will be considered an advantage, in particular experience with biochemical analyses, microscopy and in vitro cell culture procedures including transfections. english is the main language of communication at the department and internationally in science and excellent written and oral english language skills will thus be an explicit selection criterion.   outside science. copenhagen is steadily ranked among the safest and most livable cities in the world (#1 in safe city index 2021) https://edition.cnn.com/travel/a ... revealed/index.html the neighborhood nørrebro close to campus was recently ranked coolest on earth by time out magazine. https://secretkobenhavn.com/norrebro-coolest-neighborhood/ on november 1st 2021, 76% of the danish population is covid19-vaccinated and society is fully open. https://ourworldindata.org/covid-vaccinations?country=owid_wrl apart from the many sights in copenhagen and denmark, denmark sits conveniently on top of western europe and within a few hours travel of major cultural and historical cities including berlin, paris, london and rome. interested in joining us, please reach out to thomas e. jensen tejensen@nexs.ku.dk with a short motivation letter (max 1 page) and a cv. 最近导师有工作安排，11月22号前后会回复大家，安排视频通话。请耐心等待。 有兴趣的同学赶紧投简历吧。 [ last edited by mjdee on 2021-11-10 at 20:46 ] 现在还可以投简历。 明天开始汇总收到的简历，最晚周四会联系大家面试时间，请留意邮件吧。 [ last edited by mjdee on 2021-11-22 at 17:54 ] 大部分投了简历的人都收到了面试的邀请。 这个项目目前还没有合适的人选。大家还可以投简历。 专业背景不限，主要看大家的综合能力。 [ Last edited by mjdee on 2021-12-3 at 18:13 ]

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