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谢谢各位兄弟的关心，我需要的图书是：
1、.Enzymes and Their Inhibitors: Drug Development
Author: H. John Smith (Editor), Claire Simons (Editor)
Publisher: CRC
Publication Date: 2004-07-15
Number Of Pages: 328
Summary:
Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. This book describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties. This outstanding text for students in pharmacology and medicinal chemistry is also a valuable professional reference.
pdf- size: 4,2Mb
Download Details:
http://rapidshare.de/files/32793849/EaTIDD.rar
or
http://mihd.net/1.1022/Enzymes.a ... 0415334020.rar.html
2.Enzyme Systems that Metabolise Drugs and Other Xenobiotics (Current Toxicology)
Author: Costas Ioannides (Editor)
Publisher: John Wiley & Sons 2002
Publication Date: 2002-01-28
Number Of Pages: 588
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
enzyme function in the metabolism and bioactivation of xenobiotics
substrate specificity
tissue distribution
species distribution (to include laboratory animals and humans)
hormonal regulation
sex differences
modulation by prior exposure to other chemicals
age-dependent expression
pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
http://rapidshare.de/files/14336935/ES***AOX.rar
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