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小木虫论坛-学术科研互动平台 » 生物医药区 » 新药研发 » 快捷药讯 » 【讨论】关于俄罗斯今年上市的一个新药
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loulou74

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http://www.hotlek.ru/eng/ingavirin找到他们的网站,没看出什么结构,drugfuture上也搜不到
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fighting
11楼2009-08-18 09:04:45
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匿名

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12楼2009-08-18 10:09:29
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lyman829

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就是,scifinder上能查到CAS号,但是没结构,真的奇怪
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13楼2009-08-18 11:47:24
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maitians

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Ingavirin® - drug destined for new direction in the flu therapy


Three months ago one of the largest Russian pharmaceutical company Valenta have launched new antiviral product.

Ingavirin® – original innovative domestic product developed by Russian scientists including military virologists under supervision of the Chief Therapist of Russian Federation, Academician of RAS Alexander G. Chuchalin.

Product was registered in August, 2008 and was presented in the market in January 2009. Registration certificate LSR  – 006330/08.

       High antiviral efficacy was showed in the trials in vitro and in vivo to the A grippe (subtypes H3N2, H1N1, H5N1), experimental  B virus, adenoviruses.
       Ingavirin® suppresses virus replication in the nuclear stage of the cycle. Antiviral efficacy of Ingavirin® to A virus is realized by the inhibition of the newly synthesized viral NP-protein migration from cytoplasm to nucleus, which is necessary for the infectious process in the  infected cells.
In distinction from the existing products aimed for the flu treatment Ingavirin is operating to the new protein target - NP-protein. Ingavirin is the only antiviral product providing cell protection by the abruption of the virus multiplication. Expectancy of the resistance evolution is extremely small.
       Clinical trials of Ingavirin® within I, II, III phases of trials were fulfilled in the specialized research centers of Russia under guidance of Professor of the Ivanovsky Scientific Institute of Virology Kolobukhina L.V. High curative efficacy and safety was proven.
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14楼2009-08-20 21:31:38
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lyman829

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结构结构结构啊~~~~
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15楼2009-08-21 11:39:06
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Z.Zhang

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没专利的新药，今天是你的，明天就共产主义了。
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16楼2009-08-21 16:52:35
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lyman829

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不可能都上市了还没有专利吧
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17楼2009-08-21 17:10:18
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lyman829

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这个药还有两个名字哦,大家帮忙找找, dicarbamin 和 vitaglutam
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18楼2009-08-27 15:55:24
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hanbin618

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19楼2009-08-27 19:31:24
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stevesluo

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Dacarbazine
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dacarbazine  
Systematic (IUPAC) name
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
Identifiers
CAS number 4342-03-4
ATC code L01AX04
PubChem 2942
DrugBank APRD00331
ChemSpider 10481959
Chemical data
Formula C6H10N6O  
Mol. mass 182.18
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5 hours
Excretion 40% renal (unchanged)
Therapeutic considerations
Pregnancy cat. C

Legal status ℞ Prescription only

Routes IV
Y(what is this?)  (verify)

Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. Antineoplastic drugs are drugs which interfere with cell growth and impede the formation of new tissue - in this case, tumor tissue. These drugs are also known as cytotoxic drugs. Dacarbazine belongs to the family of chemicals known as alkylating agents. Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the immediate supervision of a doctor or nurse.

Contents [hide]
1 History
2 Side effects
3 Common uses
4 Experimental
5 Suppliers
6 See also
7 Sources


[edit] History
See also: History of cancer chemotherapy
Dacarbazine gained FDA approval in May 1975 as DTIC-Dome. The drug was initially marketed by Bayer.

[edit] Side effects
Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability to fight infection or disease). Dacarbazine is considered to be highly emetogenic, and most patients will be pre-medicated with antiemetic drugs like palonosetron or aprepitant. Other significant side effects include headache, fatigue and occasionally diarrhea.

[edit] Common uses
As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin lymphoma, and in the MAID regimen for sarcoma.

[edit] Experimental
Dacarbazine + Oblimersen. In clinical trials for malignant melanoma.

[edit] Suppliers
Bayer continues to supply DTIC-Dome. There are also generic versions of dacarbazine available from APP, Bedford, Mayne Pharma and Sicor (Teva).
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20楼2009-12-10 12:48:23
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