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fishwater

铁杆木虫 (职业作家)

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hdzy2001

木虫 (著名写手)


fishwater(金币+1,VIP+0):谢谢 5-15 11:02
喷雾干燥具传热快,水分蒸发迅速,干燥时间瞬间的特点,且制品质量好,质地松脆,溶解性能也好,能改善某些制剂的溶出速率,适用于热敏性药物,此外,喷雾干燥还可用于制备微囊。
2楼2009-05-14 11:41:32
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mrzouhao

木虫之王 (文坛精英)

★ ★ ★ ★ ★
fishwater(金币+5,VIP+0):非常感谢 5-15 11:02
Spray drying is a commonly used method of drying a liquid feed through a hot gas. Typically, this hot gas is air, but sensitive materials such as pharmaceuticals, and solvents like ethanol require oxygen-free drying and nitrogen gas is used instead. The liquid feed varies depending on the material being dried and is not limited to food or pharmaceutical products, and may be a solution, colloid or suspension. This process of drying is a one step rapid process and eliminates additional processing.

The liquid feed is pumped through an atomiser device that produces fine droplets into the main drying chamber. Atomisers vary with rotary, single fluid, two-fluid, and Ultrasonic Nozzle designs. These different styles have different advantages and disadvantages depending on the application of the spray drying required. In some instances a Spray Nozzle is used in place of an atomiser for a different dispersion rate.

The hot drying gas can be passed as a co-current or counter-current flow to the atomiser direction. The co-current flow enables the particles to have a lower residence time within the system and the particle separator (typically a cyclone device) operates more efficiently. The counter-current flow method enables a greater residence time of the particles in the chamber and usually is paired with a fluidised bed system.

Spray drying often is used as an encapsulation technique by the food and pharmaceutical industries. A substance to be encapsulated (the load) and an amphipathic carrier (usually some sort of modified starch) are homogenized as a suspension in water (the slurry). The slurry is then fed into a spray drier, usually a tower heated to temperatures well over the boiling point of water.

As the slurry enters the tower, it is atomized. Partly because of the high surface tension of water and partly because of the hydrophobic/hydrophilic interactions between the amphipathic carrier, the water, and the load, the atomized slurry forms micelles. The small size of the drops (averaging 100 micrometers in diameter) results in a relatively large surface area which dries quickly. As the water dries, the carrier forms a hardened shell around the load.

Load loss is usually a function of molecular weight. That is, lighter molecules tend to boil off in larger quantities at the processing temperatures. Loss is minimized industrially by spraying into taller towers. A larger volume of air has a lower average humidity as the process proceeds. By the osmosis principle, water will be encouraged by its difference in fugacities in the vapor and liquid phases to leave the micelles and enter the air. Therefore, the same percentage of water can be dried out of the particles at lower temperatures if larger towers are used. Alternatively, the slurry can be sprayed into a partial vacuum. Since the boiling point of a solvent is the temperature at which the vapor pressure of the solvent is equal to the ambient pressure, reducing pressure in the tower has the effect of lowering the boiling point of the solvent.

The application of the spray drying encapsulation technique is to prepare "dehydrated" powders of substances which do not have any water to dehydrate. For example, instant drink mixes are spray dries of the various chemicals which make up the beverage. The technique was once used to remove water from food products; for instance, in the preparation of dehydrated milk. Because the milk was not being encapsulated and because spray drying causes thermal degradation, milk dehydration and similar processes have been replaced by other dehydration techniques. Skim milk powders are still widely produced using spray drying technology around the world, typically at high solids concentration for maximum drying efficiency. Thermal degradation of products can be overcome by using lower operating temperatures and larger chamber sizes for increased residence times.

Recent research is now suggesting that the use of spray-drying techniques may be an alternative method for crystallisation of amorphous powders during the drying process since the temperature effects on the amorphous powders may be significant depending on drying residence times.
3楼2009-05-14 11:50:27
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fishwater

铁杆木虫 (职业作家)

非常感谢,如果你附上你的文献
我会引用的
引用回帖:
Originally posted by mrzouhao at 2009-5-14 11:50:
Spray drying is a commonly used method of drying a liquid feed through a hot gas. Typically, this hot gas is air, but sensitive materials such as pharmaceuticals, and solvents like ethanol require  ...

4楼2009-05-14 14:25:00
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