| ²é¿´: 103 | »Ø¸´: 1 | |||
| µ±Ç°Ö÷ÌâÒѾ´æµµ¡£ | |||
С²Ý5559°æÖ÷
|
[½»Á÷]
ÇóÖú£ºÒ©·ÖÎÄÏ׵ķÒë
|
||
|
ÓÐÆªÎÄÏ×£¬×Ô¼º·ÁËһϣ¬µ«ÊǾõµÃºÜ¶àµØ·½²»¶®£¬µ«Ìô³öÀ´ÓÖ¾õµÃÖ§ÀëÆÆËéµÄ ²»ÖªµÀ¿É·ñÇëÓ¢Óï¸ßÊÖÇ¿ÊÖ··¡¡ HPLC of basic drugs on microparticulate strongcation-exchange materials D a review£¨ÎÒÁ¬ÌâÄ¿¶¼×éÖ¯²»µ½Ò»Æð£¡£¡£© AbstractPropylsulphonicacid(SCX)-modi?edsilicaHPLCcolumnsusedwithmethanoloraqueousmethanoleluentsofappropriatepH and ionic strength can give good retention and peak shape for basic drugs. In the system studied, eluent pH in¡¥uencedretention via protonation of basic analytes, the pKaof the analyte indicating the pH where retention begins to decrease atconstant ionic strength. At constant pH, retention is inversely proportional to ionic strength for protonated bases andquaternaryammoniumcompounds.Theunderlyingretentionmechanismappearstobeion-exchangewiththeSCXmoieties,although ionized surface silanols may also contribute to retention at higher eluent pH values. In capillaryelectrochromatography (CEC) unprecedented ef?ciencies, but similar selectivity, to that observed in conventional HPLChave been obtained for a standard range of basic drugs using Waters Spherisorb S3SCX.SCX-modi?ed silica columns can be used in the HPLC of many basic drugs, including some compounds that are poorlyretained on unmodi?ed silica using methanol-rich eluents. N-Desalkyl and sulphoxide metabolites are often resolved at anappropriate eluent pH. Even analogues differing by a methylene unit in a side-chain remote from a basic centre are oftenresolved.ApplicationsofWatersSpherisorbS5SCXcolumnsincludeHPLCofantimalarialssuchaschloroquineandquinine,cardioactive drugs, for example amiodarone and ¡¥ecainide, antipsychotics (clozapine, olanzapine), and antidepressants(amitriptyline, clomipramine, dothiepin, ¡¥uoxetine) and their N-desalkyl metabolites. Major practical features of thesesystemsarethat(i)acidicandneutralcompoundsarenotretained,(ii)solventextractscanbeinjecteddirectly,and(iii)eluentrecyclingcan be performed routinely. # 2001 Elsevier Science Ireland Ltd. All rights reserved. |
» ²ÂÄãϲ»¶
һ־Ըͬ¼Ã´óѧ323·Ö£¨080500£©Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
330·ÖÇóµ÷¼Á
ÒѾÓÐ7È˻ظ´
336Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
285Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
µ÷¼ÁÍÆ¼ö
ÒѾÓÐ9È˻ظ´
²ÄÁϵ÷¼Á
ÒѾÓÐ6È˻ظ´
²ÄÁÏר˶322·Ö
ÒѾÓÐ3È˻ظ´
321Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
301Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
085600£¬321·ÖÇóµ÷¼Á
ÒѾÓÐ13È˻ظ´

С²Ý5559
°æÖ÷
![]()
![]()
![]()
![]()
- Ó¦Öú: 25 (СѧÉú)
- ¹ó±ö: 0.01
- ½ð±Ò: 905.6
- É¢½ð: 557
- ºì»¨: 7
- Ìû×Ó: 776
- ÔÚÏß: 105Сʱ
- ³æºÅ: 709303
- ×¢²á: 2009-02-26
- ÐÔ±ð: MM
- רҵ: »¯Ñ§»·¾³ÎÛȾÓ뽡¿µ
xiaohezi7844(½ð±Ò+5,VIP+0):thanks 5-2 08:24
xiaohezi7844(½ð±Ò-5,VIP+0):¿´´í£¬²»ºÃÒâ˼ 5-2 08:25
xiaohezi7844(½ð±Ò-5,VIP+0):¿´´í£¬²»ºÃÒâ˼ 5-2 08:25
|
ÎÒ²¹ÉÏÔÎÄÏ׺Í×Ô¼ºµÄ·Òë°É Èç¹ûÓиßÊÖ¿É·ñ°ïÎÒ¿´¿´~ Àï±ßÓÐЩµØ·½²»»á· |

2Â¥2009-05-01 22:47:31














»Ø¸´´ËÂ¥