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求助：药分文献的翻译
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有篇文献，自己翻了一下，但是觉得很多地方不懂，但挑出来又觉得支离破碎的 不知道可否请英语高手强手翻翻…… HPLC of basic drugs on microparticulate strongcation-exchange materials D a review（我连题目都组织不到一起！！） AbstractPropylsulphonicacid(SCX)-modi?edsilicaHPLCcolumnsusedwithmethanoloraqueousmethanoleluentsofappropriatepH and ionic strength can give good retention and peak shape for basic drugs. In the system studied, eluent pH inˉuencedretention via protonation of basic analytes, the pKaof the analyte indicating the pH where retention begins to decrease atconstant ionic strength. At constant pH, retention is inversely proportional to ionic strength for protonated bases andquaternaryammoniumcompounds.Theunderlyingretentionmechanismappearstobeion-exchangewiththeSCXmoieties,although ionized surface silanols may also contribute to retention at higher eluent pH values. In capillaryelectrochromatography (CEC) unprecedented ef?ciencies, but similar selectivity, to that observed in conventional HPLChave been obtained for a standard range of basic drugs using Waters Spherisorb S3SCX.SCX-modi?ed silica columns can be used in the HPLC of many basic drugs, including some compounds that are poorlyretained on unmodi?ed silica using methanol-rich eluents. N-Desalkyl and sulphoxide metabolites are often resolved at anappropriate eluent pH. Even analogues differing by a methylene unit in a side-chain remote from a basic centre are oftenresolved.ApplicationsofWatersSpherisorbS5SCXcolumnsincludeHPLCofantimalarialssuchaschloroquineandquinine,cardioactive drugs, for example amiodarone and ˉecainide, antipsychotics (clozapine, olanzapine), and antidepressants(amitriptyline, clomipramine, dothiepin, ˉuoxetine) and their N-desalkyl metabolites. Major practical features of thesesystemsarethat(i)acidicandneutralcompoundsarenotretained,(ii)solventextractscanbeinjecteddirectly,and(iii)eluentrecyclingcan be performed routinely. # 2001 Elsevier Science Ireland Ltd. All rights reserved. |
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2楼2009-05-01 22:47:31
