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runinwind

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[资源] 免金币Thurston_Chemistry and Pharmacology of Anticancer Drugs

Contents

Chapter 1

Introduction to Cancer .........................................................................1
1.1 Introduction ......................................................................................................1
1.2 Terminology .....................................................................................................1
1.3 Metastases ........................................................................................................2
1.4  Diagnosis and Screening..................................................................................3
1.5  Formation of Cancer Cells (Tumorigenesis) ...................................................4
1.6  Mechanisms of Genomic Damage...................................................................5
1.6.1 Internal Factors.....................................................................................5
1.6.1.1 Mutations ..............................................................................5
1.6.1.2  Addition or Loss of Genetic Material ..................................5
1.6.1.3 Epigenetic Changes ..............................................................5
1.6.1.4 Modiﬁed Gene Expression ...................................................7
1.6.2 External Factors ...................................................................................7
1.6.2.1 Viruses...................................................................................7
1.6.2.2 Bacterial Infections...............................................................8
1.6.2.3 Chemicals..............................................................................8
1.6.2.4 Radioactivity .......................................................................10
1.6.2.5 Electromagnetic Radiation..................................................10
1.6.2.6 Cancer Treatments ..............................................................11
1.6.3 Hereditary Factors..............................................................................12
1.7 Treatments ......................................................................................................12
1.7.1 Surgery ...............................................................................................12
1.7.2 Radiotherapy ......................................................................................13
1.7.3 Photodynamic Therapy (PDT) ...........................................................14
1.7.4  Biological Response Modifying Agents ............................................14
1.7.5 Chemotherapy ....................................................................................14
1.8  Discovery of Anticancer Drugs and Preclinical Evaluation..........................15
1.9  Accessibility of Drugs to Tumor Cells..........................................................17
1.10 Achieving Selective Toxicity .........................................................................17
1.11  Limiting the Toxicity of Chemotherapeutic Agents......................................18
1.11.1  Dose Scheduling and Cell Cycle.......................................................18
1.11.2 Use of Adjuvants................................................................................20
1.11.3  Novel Formulations and Prodrugs .....................................................20
1.11.4  The Cold Cap.....................................................................................20
1.11.5  Pharmacogenomic Markers of Toxicity.............................................20
1.12  Overview of Mechanisms of Action of Chemotherapeutic Agents ..............21
1.13 Drug Resistance .............................................................................................23
1.14 Combination Chemotherapy ..........................................................................25
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