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免金币Thurston_Chemistry and Pharmacology of Anticancer Drugs
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 ContentsChapter 1 Introduction to Cancer .........................................................................1 1.1 Introduction ......................................................................................................1 1.2 Terminology .....................................................................................................1 1.3 Metastases ........................................................................................................2 1.4 Diagnosis and Screening..................................................................................3 1.5 Formation of Cancer Cells (Tumorigenesis) ...................................................4 1.6 Mechanisms of Genomic Damage...................................................................5 1.6.1 Internal Factors.....................................................................................5 1.6.1.1 Mutations ..............................................................................5 1.6.1.2 Addition or Loss of Genetic Material ..................................5 1.6.1.3 Epigenetic Changes ..............................................................5 1.6.1.4 Modified Gene Expression ...................................................7 1.6.2 External Factors ...................................................................................7 1.6.2.1 Viruses...................................................................................7 1.6.2.2 Bacterial Infections...............................................................8 1.6.2.3 Chemicals..............................................................................8 1.6.2.4 Radioactivity .......................................................................10 1.6.2.5 Electromagnetic Radiation..................................................10 1.6.2.6 Cancer Treatments ..............................................................11 1.6.3 Hereditary Factors..............................................................................12 1.7 Treatments ......................................................................................................12 1.7.1 Surgery ...............................................................................................12 1.7.2 Radiotherapy ......................................................................................13 1.7.3 Photodynamic Therapy (PDT) ...........................................................14 1.7.4 Biological Response Modifying Agents ............................................14 1.7.5 Chemotherapy ....................................................................................14 1.8 Discovery of Anticancer Drugs and Preclinical Evaluation..........................15 1.9 Accessibility of Drugs to Tumor Cells..........................................................17 1.10 Achieving Selective Toxicity .........................................................................17 1.11 Limiting the Toxicity of Chemotherapeutic Agents......................................18 1.11.1 Dose Scheduling and Cell Cycle.......................................................18 1.11.2 Use of Adjuvants................................................................................20 1.11.3 Novel Formulations and Prodrugs .....................................................20 1.11.4 The Cold Cap.....................................................................................20 1.11.5 Pharmacogenomic Markers of Toxicity.............................................20 1.12 Overview of Mechanisms of Action of Chemotherapeutic Agents ..............21 1.13 Drug Resistance .............................................................................................23 1.14 Combination Chemotherapy ..........................................................................25 http://www.namipan.com/d/087985ed045229a598f486b515401cace1c7d7445d1fbc00 |
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