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[求助]
一段话在线翻译，关于DNA的，求大牛们帮忙，十万火急，在线等
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DNA oxidative damage is usually caused by highly reactive oxygen species (ROS), such as singlet oxygen, superoxide, hydrogen peroxide, and hydroxyl radical. Many chemical modifications in DNA damage (e.g.DNA cleavage, DNA-protein cross links, purine oxidation, etc.) stem from the reactions with ROS, in particular with hydroxyl radical (HO•  . Hydroxyl radical is very rare in a living cell, but extremely reactive, scrambling electrons and hydrogen atoms from protein and metabolites in a diffusive manner, and even from stable biomolecules such as DNA and lipids. Both the heterocy lic base and sugar-phosphate backbone are vulnerable, in particular via electron abstraction on guanine base and hydrogen abstraction on ribose 5′-C. If the nucleobase-repair systems are not able to immediately regenerate intact nucleobase, a mutation in genome would result from erroneous base pairing during replication or, consequently, DNA cleavage would occur consequently. It is also believed that metal ions such as iron and copper would enhance hydroxyl radical generation via Fenton chemistry.In short, DNA oxidative damage seems to begin with one-electron loss and formation of a radical cation “hole”at the encounter position. The hole hops reversibly through electronic structure along the DNA helix, trapped at a guanine-rich place as a form of guanine radical cation (G•+). Hydrolysis of G•+ releases 8-hydroxy-2′-deoxyguanosine (8-OHdG), upon consequential DNA repairing in vivo 最主要翻译最后两句In short以后的 |
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2楼2017-03-05 22:35:49
3楼2017-03-10 22:47:15
