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北京石油化工学院2026年研究生招生接收调剂公告
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Davilkid

新虫 (初入文坛)

[求助] 一段话在线翻译,关于DNA的,求大牛们帮忙,十万火急,在线等

DNA oxidative damage is usually caused by highly reactive oxygen species (ROS), such as singlet oxygen, superoxide, hydrogen peroxide, and
hydroxyl radical. Many chemical modifications in DNA damage (e.g.DNA cleavage, DNA-protein cross links, purine oxidation, etc.) stem from the reactions with ROS, in particular with hydroxyl radical (HO•. Hydroxyl radical is very rare in a living cell, but extremely reactive, scrambling electrons and
hydrogen atoms from protein and metabolites in a diffusive manner, and even from stable biomolecules such as DNA and lipids. Both the heterocy
lic base and sugar-phosphate backbone are vulnerable, in particular via electron abstraction on guanine base and hydrogen abstraction on ribose 5′-C. If the nucleobase-repair systems are not able to immediately regenerate intact nucleobase, a mutation in genome would result from erroneous base pairing during replication or, consequently, DNA cleavage would occur consequently. It is also believed that metal ions such as iron and copper would enhance hydroxyl radical generation via Fenton chemistry.In short, DNA oxidative damage seems to begin with one-electron loss and
formation of a radical cation “hole”at the encounter position. The hole hops reversibly through electronic structure along the DNA helix, trapped
at a guanine-rich place as a form of guanine radical cation (G•+). Hydrolysis of G•+ releases 8-hydroxy-2′-deoxyguanosine (8-OHdG), upon consequential DNA repairing in vivo         最主要翻译最后两句In short以后的

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Davilkid

新虫 (初入文坛)

这是关于DNA氧化损伤的,这个hole到底是什么意思,还有这句The hole hops reversibly through electronic structure along the DNA helix
2楼2017-03-05 22:35:49
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西凉腾少

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【答案】应助回帖

引用回帖:
2楼: Originally posted by Davilkid at 2017-03-05 22:35:49
这是关于DNA氧化损伤的,这个hole到底是什么意思,还有这句The hole hops reversibly through electronic structure along the DNA helix

我今天也看了这样的文献,hole 的意思是空穴

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3楼2017-03-10 22:47:15
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