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[交流] 求助：烟拉文的合成！

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专业: 化工

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【药物名称】Nicaraven, AVS, Antevas
化学结构式(Chemical Structure):

参考文献No. 46494
标题: Nicotinamide derivative, process dor preparing the same and pharmaceutical composition containing the same
作者: Mori, T.; Takaku, S.; Matsuura, F.; Murakami, Y.; Noda, Y.; Yamazaki, T.; Neichi, T.; Nakakimura, H.; Kataoka, S. (Chugai Pharmaceutical Co. Ltd.)
来源: EP 0029602; JP 56075474

合成路线图解说明:
This compound can be obtained by three different ways: 1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine. 2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF. 3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).
参考文献No. 67136
标题: AVS
作者: Grau, M.; Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源: Drugs Fut 1983,8(6),485

合成路线图解说明:
This compound can be obtained by three different ways: 1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine. 2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF. 3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).