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小马HH

新虫 (正式写手)


[资源] 关于有机电合成的文章,发在顶尖期刊nature上,谢谢虫友flywheel的文献应助。

文章采用常规碳材料,考察了烯丙位C-H键的电化学氧化,实验不用不用除氧气和除水,采用的是无隔膜电解槽。很方便,并且进行了放大研究。
    希望对各位有机电合成的朋友有用。。。题目:
Scalable and sustainable electrochemical allylic C–H oxidation
作者信息如下:
1Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA. 2Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457,
China. 3Chemical Development, Bristol–Myers Squibb, New Brunswick, New Jersey 08903, USA.
*These authors contributed equally to this work.

摘要
New methods and strategies for the direct functionalization of C–H bonds are beginning to reshape the field of retrosynthetic analysis, affecting the synthesis of natural products, medicines and materials1. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied
C–H functionalization, owing to the utility of enones and allylic alcohols as versatile intermediates, and their prevalence in natural and unnatural materials2. Allylic oxidations have featured in hundreds of syntheses, including some natural product syntheses regarded as “classics”3. Despite many attempts to improve the
efficiency and practicality of this transformation, the majority of conditions still use highly toxic reagents (based around toxic elements such as chromium or selenium) or expensive catalysts (such as palladium or rhodium)2. These requirements are
problematic in industrial settings; currently, no scalable and sustainable solution to allylic oxidation exists. This oxidation strategy is therefore rarely used for large-scale synthetic applications, limiting the adoption of this retrosynthetic strategy
by industrial scientists. Here we describe an electrochemical C–H oxidation strategy that exhibits broad substrate scope, operational simplicity and high chemoselectivity. It uses inexpensive and readily available materials, and represents a scalable allylic C–H oxidation (demonstrated on 100 grams), enabling the adoption of this C–H oxidation strategy in large-scale industrial settings
without substantial environmental impact.

[ Last edited by 小马HH on 2016-5-3 at 13:15 ]
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小马HH

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引用回帖:
11楼: Originally posted by 晓权 at 2016-05-03 17:12:11
文章中的 rvc貌似只有美国有,中国是买不到的

文献中倒是看到几次了,似乎都是小规模电解过程中用到。目前只看到过图片,没有见过实物。。
18楼2016-05-05 13:52:01
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fuzheng0721

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★★★★★ 五星级,优秀推荐

膜拜,idea很好。楼主牛人
3楼2016-05-02 16:47:54
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小马HH

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引用回帖:
3楼: Originally posted by fuzheng0721 at 2016-05-02 16:47:54
膜拜,idea很好。楼主牛人

别人的文章,,我只是在默默的拜读。。。
7楼2016-05-03 13:07:14
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晓权

银虫 (小有名气)


楼主是在美国完成的工作吗??

发自小木虫Android客户端
10楼2016-05-03 17:10:22
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muxinjin2楼
2016-05-02 16:23   回复  
五星好评  顶一下,感谢分享!
2016-05-02 16:48   回复  
顶一下,感谢分享!
2016-05-02 21:14   回复  
五星好评  顶一下,感谢分享!
zxf9846楼
2016-05-03 09:01   回复  
五星好评  顶一下,感谢分享!
hunantao8楼
2016-05-03 13:32   回复  
五星好评  顶一下,感谢分享!
tigeryihu9楼
2016-05-03 14:25   回复  
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gengxin6012楼
2016-05-03 20:11   回复  
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2016-05-03 22:27   回复  
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lwg314楼
2016-05-04 11:41   回复  
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