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[资源] Ion Channels and Their Inhibitors

Ion Channels and Their Inhibitors
Satya Prakash Gupta,
Springer
2011
ISBN-10: 3642199216, 364244282X

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

Structural and Functional Discrimination of Membrane Proteins . . . . . . . . . 1
M. Michael Gromiha, Yu-Yen Ou, and Shu-An Chen
Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 33
Patrick Bois, Aurelien Chatelier, Jocelyn Bescond, and Jean-Franc¸ois Faivre
Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers . . . . . . . . . . . . . . . . . . . . . . .  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
Supa Hannongbua, Witcha Treesuwan, and Warabhorn Boonyarat
Advances in Design and Development of Sodium Channel Blockers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
Valentina Zuliani, Laura Amori, and Mirko Rivara
Potassium Channel Blockers as Antiarrhythmic Agents . . . . . . . . . . . . . . . . . . 117
Qidong You, Qian Yang, and Xiaojian Wang
hERG Potassium Channels in Drug Discovery and Development . . . . . . . . 149
Jitendra N. Singh and Shyam S. Sharma
Prediction of hERG Channel Inhibition Using In Silico Techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Andrea Schiesaro and Gerhard F. Ecker
Advances in Structure–Activity Relationship Studies on Potassium Channel Modulators .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
Brij K. Sharma, Prithvi Singh, and Yenamandra S. Prabhakar
Calcium Ion Channels and Their Blockers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Dimitra Hadjipavlou-Litina
Therapeutic Potential of N-Type Voltage-Gated Ca2+ Channel . . . . . . . . . . 289
C. Gopi Mohan, Ashish Pandey, and Jignesh Mungalpara
Chloride Ion Channels: Structure, Functions, and Blockers . . . . . . . . . . . . . 309
Satya P. Gupta and Preet K. Kaur
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341

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