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分类 共搜索到 85 个相关话题(最多显示前5000个) 作者 最后发表
文献求助 Discovery of AMG 193,an MTA-Cooperative PRMT5 Inhibitor for ...
DiscoveryofAMG193,anMTA-CooperativePRMT5InhibitorfortheTreatmentofMTAP-DeletedCancersLipingHPettus1,MatthewBourbeau1,NuriaATamayo1,AlbertAmegadzie1,DianeBeylkin1,ShonKBooker1,...
 piu031111 2025-09-15 02:47
生物科学 CRISPR文库与肿瘤免疫共培养：精准破解免疫治疗新靶点
在这些调节器中，PRMT1和RIPK1分别被确定为一种双重免疫抵抗...γ信号通路的基因的缺失增加了K562细胞的易感性，加入IFN-γ中和抗体增加了K562细胞对NK细胞杀伤作用的敏感性[5]。3.展望CRISPR...
 我太秀了 2025-03-25 08:57
文献求助 求文献一篇，谢谢:DOI:10.2174/1568026623666230712120527
Wu,LintaoResearchProgressonSmall-moleculeInhibitorsofProteinArginineMethyltransferase5(PRMT5)forTreatingCancerCURRENTTOPICSINMEDICINALCHEMISTRY2023Volume23Issue21Page2048-...
 zzgbest007 2024-12-16 05:23
文献求助 Protein Arginine Methyltransferase 5(PRMT
LiangM,WangL,TianX,etal.IdentificationandValidationofAnti-ProteinArginineMethyltransferase5(PRMT5)AntibodyasaNovelBiomarkerforSystemicSclerosis(SSc)AnnalsoftheRheumaticDiseases...
 beilei001 2024-08-17 09:03
文献求助 求一篇文献，有链接，万分感谢
ChantadaAmyL.WhittakerDavidM.WilsonJonJ.Winter-HoltDiscoveryandInVivoEfficacyofAZ-PRMT5i-1,aNovelPRMT5InhibitorwithHighMTACooperativityJ.Med.Chem.2024,XXXX,XXX,XXX-XXXJ.Med....
 shangsiyun 2024-08-07 08:34
绿色求助(高悬赏) Journal of Medicinal Chemistry 2024 ...
JamesM.Smith*BernardBarlaamDiscoveryandInVivoEfficacyofAZ-PRMT5i-1,aNovelPRMT5InhibitorwithHighMTACooperativityJournalofMedicinalChemistry2024July30,2024...
 wei_qunchao 2024-08-05 12:51
文献求助 A Selective,Brain Penetrant,MTA-Cooperative PRMT5
KevinM.Cottrell*KevinM.CottrellDiscoveryofTNG908:ASelective,BrainPenetrant,MTA-CooperativePRMT5InhibitorThatIsSyntheticallyLethalwithMTAP-DeletedCancersJMC20246064–608010.1021...
 大城小事 2024-05-16 01:44
文献求助 A Selective,Brain Penetrant,MTA-Cooperative PRMT5
KevinM.Cottrell*KevinM.CottrellDiscoveryofTNG908:ASelective,BrainPenetrant,MTA-CooperativePRMT5InhibitorThatIsSyntheticallyLethalwithMTAP-DeletedCancersJMC20246064–608010.1021...
 大城小事 2024-05-16 06:06
文献求助 A Selective,Brain Penetrant,MTA-Cooperative PRMT5 Inhibit
HonglingYuan,MinjieZhang,WenhaiZhang,AlanHuang,andJohnP.MaxwellDiscoveryofTNG908:ASelective,BrainPenetrant,MTA-CooperativePRMT5InhibitorThatIsSyntheticallyLethalwithMTAP-...
 911le 2024-04-15 01:14
文献求助 PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine ...
CongJiang1,JingLiu2,ShaohuiHe3,WeiXu3,RunzhiHuang4,WeijuanPan5,XiaolongLi6,XiaomingDai2,JianpingGuo2,TaoZhang2,HiroyukiInuzuka2,PingWang4,JohnMAsara2,JianruXiao7,WenyiWeiPRMT1...
 zqw徒弟 2024-04-08 04:21
文献求助 The PRMT5 inhibitor C9 mitigates hypoxia-induced carboplatin...
JiangjiangFan1,HaichaoLi1,QiongRuan2,XimingZhu1,PengyuJing1,ZhongpingGu1ThePRMT5inhibitorC9mitigateshypoxia-...
 tanjuan135 2023-08-07 04:14
文献求助 An Inhibitor of the PRMT
ThomasScattolin,DavidR.Snead,DineshJ.Paymode,SaharRoshandel,ChenXie,GuihuiChen,andCheng-yiChenScalableAtroposelectiveSynthesisofMRTX1719:AnInhibitorofthePRMT5/MTAComplexOrg....
 落叶归根pxs 2023-07-31 03:46
文献求助 求中文期刊一篇，请尽量不要给网盘地址
何伶靖;邹成;贺琴菊;冯宇晴;张定校PRMT5在癌症中的研究进展中国细胞生物学学报2021,v.43662-674DOI：CNKI:SUN:XBZZ.0.2021-03-022
 zhangboandy0204 2023-05-08 05:05
文献求助 Loss of PRMT7 reprograms glycine metabolism to selectively ...
ChangLiu1,WaiyiZou2,DanianNie3,ShuyiLi1,ChenDuan1,MinZhou1,PeilongLai4,ShengyongYang5,SenJi5,YangqiuLi6,MeiMei7,ShilaiBao7,YanliJin1,JingxuanPanLossofPRMT7...Issue6,7June2022,...
 aixintian 2023-03-11 08:40
新药研发 “合成致死”新兴靶点研发进展汇总
PRMT5作用机制2016年，发表在《Science》的文章首次报道了抑制PRMT5在MTAP（甲硫腺苷磷酸化酶）缺失肿瘤中的“合成致死”效应，文章指出与PRMT5构成合成致死的基因是MTAP，这是一种抑癌基因...
 药渡数据 2023-02-17 02:50
文献求助 文献求助：Discovery of novel PRMT5 inhibitors bearing a ...
XinyuBai,ZhengZhai,XuyangZhao,RidongLi,LingLiang,YanJin&YuxinYinDiscoveryofnovelPRMT5inhibitorsbearingamethylpiperazinylmoietyFutureMedicinalChemistry20222021-0244....
 18363882821 2022-11-15 08:49
文献求助 求助文献Fragment-Based Discovery of MRTX1719,a Synthetic ...
AllField=Fragment-Based+Discovery+of+MRTX1719%2C+a+Synthetic+Lethal+Inhibitor+of+the+PRMT5%E2%80%A2MTA+Complex+for+the+Treatment+of+MTAP-Deleted+Cancers求助文献期望是正式刊发版...
 大城小事 2022-11-07 01:45
文献求助 求助SCI论文一篇，附链接
YilongWang#1,ShuYan#23,XuemeiLiu4,FeiDeng5,PengchaoWang6,LiuyeYang6,LizhiHu6,KaiHuang78,JianguiHe9PRMT4promotesferroptosistoaggravatedoxorubicin-...1982-1995.10.1038/s41418-022-...
 晰耀 2022-10-18 02:29
文献求助 文献求助
21-0620https://aacrjournals.org/mct/article-abstract/21/1/3/675132/SAM-Competitive-PRMT5-Inhibitor-PF-06939999?redirectedFrom=fulltextScienceDirect(Elsevier)(CellPress)
 执著追求 2022-10-10 12:38
文献求助 文献求助
KristenJensen-PergakesORCIDlogo;...21-0620https://aacrjournals.org/mct/article-abstract/21/1/3/675132/SAM-Competitive-PRMT5-Inhibitor-PF-06939999?redirectedFrom=fulltext
 执著追求 2022-09-28 12:34
绿色求助(高悬赏) PRMT5 regulates RNA m6A demethylation for doxorubicin ...
WuY,WangZ,HanL,GuoZPRMT5regulatesRNAm6AdemethylationfordoxorubicinsensitivityinbreastcancerMolTher2022Jul06;30(7)2022VOLUME30,ISSUE7,P2603-2617,10.1016/j.ymthe.2022.03.003...
 yaoyueliang 2022-08-10 12:03
文献求助 求助文献——PRMT4 promotes ferroptosis to aggravate ...
求助文献——PRMT4promotesferroptosistoaggravatedoxorubicin-inducedcardiomyopathyviainhibitionoftheNrf2/GPX4pathwayYilongWang,ShuYan,XuemeiLiu...doi.org/10.1038/s41418-022-00990-5...
 KLaian 2022-04-12 04:53
文献求助 文献求助SAM-Competitive PRMT5 Inhibitor PF-06939999 ...
KristenJensen-Pergakes,JohnTatlock,etcSAM-CompetitivePRMT5InhibitorPF-06939999...3-15.DOI:10.1158/1535-7163.MCT-21-0620https://mct.aacrjournals.org/content/21/1/3.full-text.pdf
 qiyue1986 2022-01-14 02:15
文献求助 Deleted Cancer Cells by Reducing PRMT
PeterKalev116MarcL.Hyer216StefanGross3ZenonKonteatis4Chi-ChaoChen5MarkFletcher5MaxLein6EliaAguado-Fraile7VictoriaFrank1AmeliaBarnett1EvertonMandley2JoshuaGoldford8YueChen6...
 fpan2016 2021-07-28 01:23
文献求助 求知网学位论文
刘荣华蛋白质精氨酸甲基转移酶PRMT5甲基化生物学功能研究南京大学2013全文中国知网CNKI
 flying.99 2020-10-22 03:00
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