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分类	共搜索到 36 个相关话题(最多显示前5000个)	作者	最后发表

文献求助	Efficient Hit-to-Lead Searching of Kinase Inhibitor Chemical... EfficientHit-to-LeadSearchingofKinaseInhibitorChemicalSpaceviaComputationalFragmentMergingWernJuinGabrielOng,IlyaSerebriiskii,andJohnKaranicolasEfficientHit-to-...	dreaming1512	2021-11-15 11:25
文献求助	Hit-to-Lead studies:the discovery of potent,orally ... BaxterA1,CooperA,KinchinE,MoakesK,UnittJ,WallaceA.Hit-to-Leadstudies:thediscoveryofpotent,orallybioavailablethiazolopyrimidineCXCR2receptorantagonists.BioorgMedChemLett.2006Feb...	juanjuantutu	2019-01-06 09:22
文献求助	From Hit to Lead. LMologni，VMDalla，AChilin，MPalumbo，GMarzaroDiscoveryofwtRETandV804MRETInhibitors:FromHittoLead.ChemMedChem[22Jun2017,12(16):1390-1398]ChemMedChem[22Jun2017,12(16):1390-1398]...	jasperwang	2018-01-03 01:02
文献求助完结子版	BMCL文献求助 [info2]RapiddevelopmentoftwofactorIXainhibitorsfromhittoleadinfo'.2.'][info3]Bioorganic&MedicinalChemistryLettersinfo'.3.'][info4]2015info'.4.'][info5]2321–...	hoochfan	2017-11-09 01:06
文献求助	求文献的Supplementary data，不是要原文 hit-to-leadoptimizationofnovelallostericglucokinaseactivatorsinfo'.2.'][info3]Bioorganic&MedicinalChemistryLettersinfo'.3.'][info4]2011info'.4.'][info5]Volume...	096879	2017-10-23 01:45
文献求助	求助Bioorganic and Medicinal Chemistry文献一篇 [info2]Substituted2-arylbenzothiazolesaskinaseinhibitors:Hit-to-leadoptimizationinfo'.2.'][info3]BioorganicandMedicinalChemistryinfo'.3.'][info4]2009info'.4.']...	mercury0032	2017-09-15 05:59
文献求助	Bioorganic&Medicinal Chemistry Letters [info1]JurgenDingesaChristopherM.Harrisinfo'.1.'][info2]Hit-to-leadevaluationofanovelclassofsphingosine1-phosphatelyaseinhibitorsinfo'.2.'][info3]Bioorganic&...	gongshouzhe	2017-09-13 02:39
文献求助	文献求助 [info1]Sams,AnetteGravenetalinfo'.1.'][info2]Hit-to-leadinvestigationofaseriesofnovelcombineddopamineD2andmuscarinicM1receptorligandswithputative...	a532460201	2017-04-13 03:02
文献求助完结子版	求助文献 Seifertinfo'.1.'][info2]Discoveryandhit-to-leadoptimizationofnovelallostericglucokinaseactivatorsinfo'.2.'][info3]Bioorganic&MedicinalChemistryLettersinfo'.3.'...	yumu	2017-03-08 01:43
文献求助完结子版	求BMCL一篇 [info1]Dinges,Jurgenetalinfo'.1.'][info2]Hit-to-leadevaluationofanovelclassofsphingosine1-phospatelyaseinhibitorsinfo'.2.'][info3]Bioorganic&Medicinal...	shalake	2016-11-24 12:42
文献求助	求Bioorganic&Medicinal Chemistry Letters一篇 Nodabinfo'.1.'][info2]Discoveryandhit-to-leadoptimizationofnovelallostericglucokinaseactivatorsinfo'.2.'][info3]Bioorganic&MedicinalChemistryLettersinfo'.3.']...	chonglinghu	2016-10-08 01:05
文献求助	求文献！ Receptor1Antagonists:FromHittoLeadinfo'.2.'][info3]ACSMed.Chem.Lett.,info'.3.'][info4]August19,2016info'.4.'][info5]inpressinfo'.5.'][info6]DOI:10.1021/...	lizhuodsz	2016-09-08 01:06
文献求助	Hit-to-lead optimization of phenylsulfonyl hydrazides for a ... JaeYeolLeeainfo'.1.'][info2]Hit-to-leadoptimizationofphenylsulfonylhydrazidesforapotentsuppressorofPGE2production:Synthesis,biologicalactivity,andmolecular...	Luphere	2016-08-08 12:35
招聘信息布告栏	GIBH 招聘 workonareasfromhitvalidationthroughtoleadoptimization.Youwillbeinvolvedinthedesignandsynthesisofleadcompounds.Therolecouldincludethechanceto...	whg15	2016-06-22 05:17
文献求助	Hit-to-lead optimization of disubstituted oxadiazoles and ... [info1]ByWagner,Gaboretalinfo'.1.'][info2]Hit-to-leadoptimizationofdisubstitutedoxadiazolesandtetrazolesasmGluR5NAMsinfo'.2.'][info3]FromBioorganic&Medicinal...	馨瑞晴	2016-05-19 10:27
文献求助	求助文献一篇，非常感谢！有链接。 comprehensivelistofcitationstothisarticle,usersareencouragedtoperformasearchinSciFinder.CoverImageBiphenyl-4-carboxylicAcid[2-(1H-Indol-3-yl)-ethyl]-...	自由~流浪	2016-03-26 07:38
文献求助	文献求助 aminopyrazinesasnovel,potentNav1.7antagonists:Hit-to-leadidentificationandSARinfo'.2.'][info3]BioorganicandMedicinalChemistryLettersinfo'.3.'][info4]2012info'....	cyq0527	2016-03-21 08:10
文献求助完结子版	求助文献 [info2]HittoLeadAccountoftheDiscoveryofaNewClassofInhibitorsofPimKinasesandCrystallographicStudiesRevealinganUnusualKinaseBindingMode?info'.2.'][info...	mnbbnm123	2016-03-19 10:57
文献求助	Optimizing the hit-to-lead process using SPR analysis. stefan.lofasbiacore.cominfo'.1.'][info2]Optimizingthehit-to-leadprocessusingSPRanalysis.info'.2.'][info3]AssayDrugDevTechnol.info'.3.'][info4]2004Aug;info'....	cici毛虫	2016-03-09 02:48
文献求助	ask for a paper andhit-to-leadoptimizationofpyrrolopyrimidinesaspotent,state-dependentNav1.7antagonistsinfo'.2.'][info3]BioorganicandMedicinalChemistryLettersinfo'.3.'][info4]...	aj412	2016-03-03 11:09
文献求助	文献求助，有链接！ inhibitors—Hittoleadexplorationinfo'.2.'][info3]Bioorganic&MedicinalChemistryLettersinfo'.3.'][info4]2010info'.4.'][info5]20（17），Pages5133–5138info'.5.']...	liuguocheng	2015-09-28 06:11
文献求助	求助文献，谢谢！ [info1]BaxterA,BennionC,BentJ,etalinfo'.1.'][info2]Hit-to-Lead:thediscoveryofpotent,orallybioactivetriazolethiolCXCR2receptorantagonistinfo'.2.'][info3]2003,info'.3.']...	患难知己	2015-05-04 02:51
文献求助	Discovery and hit-to-lead optimization of 2,6-... hit-to-leadoptimizationof2,6-diaminopyrimidineinhibitorsofinterleukin-1receptor-associatedkinase4info'.2.'][info3]BMCLinfo'.3.'][info4]2015info'.4.'][info5]...	126406380	2015-04-28 01:46
文献求助完结子版	Predicting binding energies of CDK6 inhibitors in the hit-to...	匿名	2014-11-13 02:24
会议截稿子版	安东帕“微波辅助合成应用现状及发展”网络研讨会如何根据常规电热程序新建微波合成反应程序如何在微波合成在中实现条件一致的平行合成如何用微波组合化学技术来加速新药开发的Hit-to-Lead反应的优化：序贯优化和平行优化的比较微波...	放大镜	2014-05-14 01:22