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[资源] 核酸适体aptamer大牛Tan weihong 2015最新巨著 价值1750RMB

Aptamers Selected by Cell-SELEX for Theranostics
Editors: Weihong Tan, Xiaohong Fang

基本信息
出版社: Springer-Verlag Berlin and Heidelberg GmbH & Co. K; 2015 (2015年3月24日)
精装: 352页
语种: 英语
ISBN: 3662462257
条形码: 9783662462256
商品尺寸: 23.4 x 15.6 x 2.1 cm
ASIN: 3662462257

作者简介
Prof. Weihong Tan received his Ph.D. in physical chemistry from the University of Michigan, Ann Arbor in 1993. He was then named a Distinguished Postdoctoral Researcher by the US-DOE and worked at the Ames Laboratory. In 1996, he joined the University of Florida as an assistant professor of chemistry, and was promoted to associate professor (2001), full professor (2003) and distinguished professor (2012). He was named a University of Florida Research Foundation Professor (2004), and V. T and Louis Jackson Endowed Professor (2008 till now). Prof. Tan is also a professor of biomedical engineering and chemistry at Hunan University. Tan's group has developed research programs in chemical biology, bioanalysis, molecular engineering, bionanotechnology, and biomedical engineering. Currently, the Tan group is working on synthesizing a variety of DNA probes for biomedical studies and for DNA nanomotors, in developing new nanomaterials and bionanotechnology for bioanalysis, molecular imaging and drug delivery, and in elucidating the molecular basis of diseases such as cancers using a chemical biology approach. His work has been recognized by many awards, including the Pittcon Achievement Award in 2004 and the ACS Florida Award in 2012 for outstanding contributions to chemical sciences. Prof. Tan has published extensively in the field of bioanalysis, chemical biology, molecular engineering and bionanotechnology with more than 390 papers with an H-index of 88 and more than 22,500 citations. He also owns 24 patents. He is selected as "The World's Most Influential Scientific Minds 2014". Prof. Xiaohong Fang received her Ph.D. degree in analytical chemistry at Peking University (China) in 1996. After one-year postdoctoral work at the University of Waterloo (Canada), she then worked as a research associate at the University of Florida (USA) from 1998 to 2001 in Prof. Weihong Tan's group. She was recruited to the Chinese Academy of Sciences (CAS) under the "Hundred Talents Program" in December 2001, and became a professor of Chemistry at the CAS Key Laboratory of Molecular Nanostructures and Nanotechnology, Institute of Chemistry. Her main research interest is the development of new biophysical and bioanalytical methods for real-time protein detection and for the study of biomolecular interaction at the single molecule level. This includes: single-molecule imaging of protein dynamics in living cells, biomolecular interaction study by single-molecule force microscopy, novel aptamer-based molecular probes for real-time protein recognition and nanobiosenor development. She has published over 150 papers and has 18 granted patents. Her awards include Chinese National Science Fund for Distinguished Young Scholars from NSFC, Distinguished Young Investigator Award from Chinese Chemical Society, and Distinguished Hundred Talents Scholar Award from CAS, etc.

谭蔚泓,男,教授,生物分子识别方向首席科学家。“长江学者”特聘教授、湖南大学生物学院院长、湖南大学化学生物传感与计量学国家重点实验室主任。兼任美国佛罗里达大学医学院结构生物学中心大脑研究所研究员、佛罗里达大学化学系教授,美国科学促进协会(AAAS)、美国化学会(ACS)、生物医学工程学会(BES)、神经科学学会(SN)、生物光子学学会(BS)、国际光学工程学会(SPIE)等学会会员,美国光学学会组委会成员,中国国家纳米科技中心学术委员会委员。在Aptamer、纳米技术及其超小型生物传感器、生物医学实时成像、单细胞活体检测、分子触角超分子、分子信标DNA探针等研究领域取得了国际同行公认的、突出的创造性成果,主持美国国家科学基金、美国国防部基金、美国国家卫生部基金、中国国家重大基础研究计划(973计划)项目、中国高技术研究发展计划(863计划)项目、湖南省SARS专项、中国国家自然科学基金海外杰出青年学者合作研究基金等多项课题。
谭蔚泓教授先后主持了美国国家科学基金、美国国防部基金、美国国家卫生研究所基金等重要课题11项,近五年在美国获得的科研经费资助超过240万美元。在国内,他获得了国家海外杰出青年合作基金的资助。2003年获省科技厅及科技部国际合作等重点项目资助。2010年由谭蔚泓为首席科学家、湖南大学牵头申报的国家重大科学研究计划项目(973计划)“基于核酸适配体的蛋白质研究新技术和新方法”获得2011年立项资助,科研经费2730余万元。

目录
Introduction to Aptamer and Cell-SELEX.-
Cell-SELEX: Aptamer Selection against Whole Cells.-
Unnatural Nucleic Acids for Aptamer Selection.-
Cell-Specific Aptamer Characterization.-
Molecular Engineering to Enhance Aptamer's Functionality.-
Cell-Specific Aptamer-Labeled DNA Molecular Devices and Nanodevices for Molecular Imaging and Targeted Drug Delivery in Cancer Theranostics.-
Properties of Nucleic Acid Amphiphiles and Their Biomedical Applications.-
Aptamer-Based Hydrogels and Their Applications.-
Cell-Specific Aptamers for Disease Profiling and Cell Sorting.-
Using Cell-Specific Aptamer-Nanomaterial Conjugates for Cancer Cell Detection.-
Cell-Specific Aptamers for Molecular Imaging.-
Discovery of Biomarkers Using Aptamers Evolved in Cell-SELEX Method.-
Cell-Specific Aptamers for Targeted Therapy.-
Future Perspective: The Clinical Application of Cell Specific Aptamers核酸适体aptamer大牛Tan weihong 2015最新巨著 价值1750RMB
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