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ÊéÃûCHEMICAL MODULATORS
OF PROTEIN MISFOLDING
AND NEURODEGENERATIVE
DISEASE
×÷ÕßPierfausto Seneci
Universit¨¢ degli Studi di Milano,
Dipartimento di Chimica,
Ò³Êý260
³ö°æÉ簬˹ά¶û
ISBN: 978-0-12-801944-3
Abbreviations ix
1. Chemical Modulators of Protein Misfolding,
Neurodegeneration and Tau
1.1 Tau-targeted compounds 2
1.2 Ab-targeted compounds 6
2. Targeting the Protein Quality Control (PQC)
Machinery
2.1 Molecular chaperones, PQC, and neurodegeneration 25
2.2 Hsp27 26
2.3 Hsp70 36
2.4 Hsp90 43
2.5 Recap 52
3. Targeting Proteasomal Degradation of Soluble,
Misfolded Proteins
3.1 UPS-mediated degradation of misfolded proteins 73
3.2 CHIP 75
3.3 USP14 81
3.4 Recap 85
4. Targeting Unselective Autophagy of Cellular
Aggregates
4.1 Macroautophagy mediated degradation of protein aggregates 95
4.2 mTORC1 96
4.3 Small molecule enhancers of rapamycin (SMERs) 108
4.4 Recap 117¡¶Éñ¾­±äÐÔÒÔ¼°µ°°×ÖÊ´íÎóÕÛµþ¼²²¡µÄ»¯Ñ§µ÷¿Ø¡·2015×îÐÂ
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