代人发布法国 CNRS PhD offer，小伙伴们把握机会哦～
各位备战2015年国家公派留学的童鞋们～代人发布CNRS PhD offer, 具体详情请见下文，有意者请速联系！（注明：仅招收能够申请到2015年CSC奖学金的学生）
PhD offer in the field of Chemistry for Magnetic Resonance Imaging
The Centre of Molecular Biophysics, Orleans, France, is a CNRS research laboratory at the interface of chemistry, biology and physics. For several years, the Centre has been active in the development of molecular approaches in MRI and optical imaging, with state-of-the-art small animal imaging facilities and a strong focus on the chemistry related to imaging.
Our research group is interested in the design, synthesis and characterization of innovative imaging probes based on metal complexes, in particular lanthanide chelates, for applications in biomedical imaging. Our main activities involve the development of molecular magnetic resonance imaging agents for the detection of enzymatic activities, neurotransmitter concentration, amyloid plaques, etc. The objective of this project is to explore a new strategy for the development of enzymatically activated MRI probes. We propose to synthesize and characterize Gd3+ complexes conjugated to a peptide loop containing the enzyme specific substrate. Upon enzymatic cleavage, the hydration state and the rotational dynamics of the complexes are influenced, translated to an MRI response. This project calls for an expertise in synthetic and coordination chemistry.
The successful candidate will have an excellent knowledge and laboratory skills in organic synthesis of macrocyclic ligands for lanthanide chelation and should possess good understanding of the basic principles of coordination chemistry. Excellent command of English (both written and spoken) is a prerequisite for application. The candidate should be highly motivated and able to work in an international team.
This position is only for the potential candidates who are eligible for CSC application.
Contact : Eva Toth, firstname.lastname@example.org, with full CV and motivation letter.
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