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法国斯特拉斯堡大学Gertraud Orend 肿瘤免疫微环境课题组招收CSC博士生一名
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法国斯特拉斯堡大学Gertraud Orend 肿瘤免疫微环境课题组招收CSC博士生一名 课题组网站： https://orend-tme-group.com/ 如有兴趣，可发送邮件到 gertraud.orend@inserm.fr （附带CV, motivation letter） 具体情况可咨询。 In the INCa PLBIO funded project “Matrix-CAR-Targeting”: Restoration of anti-tumor immunity by targeting the extracellular matrix with CAR T cells" novel tools will be engineered to target the extracellular matrix for reprogramming the immune suppressive tumor microenvironment including peptides and CAR (chimeric antigen receptor) specific CAR-T cells. Spatial distribution, migration and activation of engineered T cells will be investigated in spheroid cultures, ex vivo tumor tissue slices, and cancer progression models. Tumor immunity, growth and lung metastasis and tumor microenvironment properties will be determined by flow cytometry, tissue staining, cytokine array and RNA seq analysis. We are accepting a highly motivated student with own funding who wants to do the PhD thesis on the above mentioned project starting in October 2023 in the Tumor Microenvironment group of Gertraud Orend (INSERM U1109, Strasbourg, France). This laboratory (https://orend-tme-group.com) is specialized on the analysis of the tumor microenvironment with particular emphasis on the extracellular matrix molecule tenascin-C (Yimaz et al., 2022, J Cell Sci, Midwood et al., 2016, J Cell Sci). This laboratory has demonstrated pivotal roles of tenascin-C in tumor angiogenesis (Saupe et al., 2013, Cell Reports, Rupp et al., 2016, Cell Reports), metastasis (Sun et al., 2018, Cancer Res, Sun et al., 2019, Mat Bio) and tumor immunity (Deligne 2020, Cancer Immun Res, Spenle et al., 2021, Front Immunol), and recently showed that tenascin-C orchestrates an immune suppressive tumor microenvironment. The novel concept of "TIL-Matrix Retention" where tenascin-C immobilizes tumor infiltrating leukocytes (TIL) could explain how matrix counteracts immune checkpoint therapy (Spenlé et al., 2020, Cancer Immun Res, Murdamoothoo et al., 2021 EMBO Mol Med). In frame of this project the candidate will apply novel CAR T cells and the recently published MAREMO peptides (Loustau et al., 2022, Mat Bio). We offer: a highly dynamic and supportive group of colleagues including researchers, postdocs, PhD and master students and technical support with expertise in extracellular matrix research, murine tumor models and tumor immunity. We search: a highly motivated student with high team spirit, good English communication skills and dedication to science. Interested candidates are invited to contract Gertraud Orend (gertraud.orend@inserm.fr) |
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