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zhangkun232

至尊木虫 (著名写手)

[交流] 绿色荧光蛋白(GFP)以及AIE聚集荧光增强效应的发光机制已有1人参与

最近,我们在绿色荧光蛋白(gfp)以及aie聚集荧光增强效应的发光机制方面取得了突破性的研究进展,提出了完全不同于传统的理论模型来解释他们的发光机制 ,希望可以引起大家更多的关注和交流。论文连接:https://pubs.acs.org/doi/10.1021/acsphyschemau.1c00020
美国化学会官方的详细推送:https://mp.weixin.qq.com/s/wrxq55hel0lok4op3mclvg

论文题目:structural water molecules confined in soft and hard nanocavities as bright color emitters
jiafeng zhou, taiqun yang, bo peng, bingqian shan, meng ding, and kun zhang*
abstract

molecules confined in the nanocavity and nanointerface exhibit rich, unique physicochemical properties, e.g., the chromophore in the β-barrel can of green fluorescent protein (gfp) exhibits tunable bright colors. however, the physical origin of their photoluminescence (pl) emission remains elusive. to mimic the microenvironment of the gfp protein scaffold at the molecule level, two groups of nanocavities were created by molecule self-assembly using organic chromophores and by organic functionalization of mesoporous silica, respectively. we provide strong evidence that structural water molecules confined in these nanocavities are color emitters with a universal formula of {x+·(oh╟·h2o)·(h2o)n−1}, in which x is hydrated protons (h3o+) or protonated amino (nh3+) groups as an anchoring point, and that the efficiency of pl is strongly dependent on the stability of the main emitter centers of the structural hydrated hydroxide complex (oh╟·h2o), which is a key intermediate to mediate electron transfer dominated by proton transfer at confined nanospace. further controlled experiments and combined characterizations by time-resolved steady-state and ultrafast transient optical spectroscopy unveil an unusual multichannel radiative and/or nonradiative mechanism dominated by quantum transient states with a distinctive character of topological excitation. the finding of this work underscores the pivotal role of structurally bound h2o in regulating the pl efficiency of aggregation-induced emission luminogens and gfp.

[ last edited by zhangkun232 on 2021-11-6 at 09:41 ]

[ Last edited by zhangkun232 on 2021-11-6 at 09:43 ]
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zhangkun232

至尊木虫 (著名写手)

文中的工作对绿色荧光蛋白(GFP)发光机制的理解是颠覆性的,同时也对AIE聚集诱导荧光增强机制的理解提出了全新的视角和解释,当然也包括所有地位量子点发光机制的理解。
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2楼2021-10-26 09:30:14
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susanf

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小木虫: 金币+0.5, 给个红包,谢谢回帖
引用回帖:
2楼: Originally posted by zhangkun232 at 2021-10-26 09:30:14
文中的工作对绿色荧光蛋白(GFP)发光机制的理解是颠覆性的,同时也对AIE聚集诱导荧光增强机制的理解提出了全新的视角和解释,当然也包括所有地位量子点发光机制的理解。

非常漂亮的工作,证据的非常的充分,将彻底改变人们对绿色荧光蛋白以及聚集诱导发光机制(AIE )的理解!
3楼2021-10-26 15:29:23
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zhangkun232

至尊木虫 (著名写手)

这篇文章也揭示了低维量子点的发光机制,如金属团簇、碳点以及半导体量子点等。几篇代表性文章的链接如下:
(1)https://www.frontiersin.org/arti ... em.2021.756993/full
(2)https://pubs.rsc.org/en/content/articlelanding/2021/nr/d1nr02389f
(3)https://www.mdpi.com/2079-4991/10/2/261
(4)https://www.nature.com/articles/s42004-019-0233-1
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4楼2021-10-30 09:23:36
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zhangkun232

至尊木虫 (著名写手)

这篇文章最终发表在美国化学刚刚出版的开放获取杂志ACS Physical Chemistry Au,投稿难度还是非常的不容易!两个副主编都是来自于JPCL 的兼职副主编。已经接受的文章档次也不低,
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5楼2021-11-02 21:04:07
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zhangkun232

至尊木虫 (著名写手)

简简单单生活,快快乐乐追求自己的梦想!
6楼2021-11-06 09:40:28
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