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悉尼大学Vigolo课题组招收全奖博士生、CSC公派留学生、博后、访问学者
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PhD/Postdoc positions My name is Daniele Vigolo and I am a Senior Lecturer (equivalent to Associate Professor) in the School of Biomedical Engineering at the University of Sydney, Australia. The main research interests of my group are in the field of soft matter, complex fluids and bio-microfluidics. We aim to answers fundamental inter-disciplinary questions in micro-fluid dynamics of multiphase flows and transport phenomena. We are in particular interested in applications of microfluidics to biological and health related problems. My group study bio-fluid dynamics with the aim to predict and prevent the insurgence of diseases such as deep vein thrombosis. Additionally, we are interested in understanding the behaviour of cells cultivated on biocompatible soft materials presenting custom stiffness pattern that we fabricated. We are also interested in studying dynamics phenomena developing close to soft interfaces (e.g., liquid-liquid or close to elastic materials) and to understand their implications. To do so we exploit lab-on-a-chip devices with which we are able to precisely control the microenvironment conditions and to design and realize functionalised advanced biocompatible materials. We are always interested in self-funded highly motivated PhD students or Postdoctoral Researchers. If you have ideas you want to discuss or if you want to apply for a fellowship (for example the CSC) to work in our lab, please drop me an e-mail at: daniele.vigolo@sydney.edu.au For more information about CSC please check here: https://www.sydney.edu.au/schola ... ms-scholarship.html https://www.sydney.edu.au/schola ... ng-scholarship.html If you are interested in microfluidics, physics, chemistry, optics, biology and most important, if you are curious to understand how things work, please consider working with us! We are working on several projects that might interest you such as: “Microfluidic manipulation of the properties of soft biocompatible materials via thermophoresis” Project description: This project aims to exploit an innovative way to locally manipulate the mechanical properties and porosity of a soft material at the micron scale, and thus develop a new class of functionalised materials exploiting thermophoresis in microfluidics (i.e. the drift induced by a temperature gradient) [Vigolo et al., Sci. Rep., 7, 2017; Vigolo et al., Soft Matter, 6, 2010; Vigolo et al., Langmuir, 26, 2010]. My group has recently demonstrated the ability to modify the stiffness of a biocompatible hydrogel by thermophoresis [Vigolo et al., Sci. Rep., 9, 2019]. In this project we aim to control the biocompatible material’s properties at the length scale typical of a single cell by creating different temperature patterns and thus a stiffness pattern. We will then cultivate cells over the material and study their response to mechanical stimuli. A crucial aim of this project is also the investigation of thermophoresis that will be performed exploiting microfluidic devices designed ad hoc and by employing advanced optical methods that will be developed during this project. The understanding of the fundamental principles behind the formation of a concentration gradient induced by the presence of a temperature gradient are paramount to be able to manipulate the final material’s properties. “Advanced in vitro and in silico models to predict and prevent deep vein thrombosis” Project description: Deep vein thrombosis (DVT) is a life-threatening and debilitating condition where blood clots form within the deep veins (e.g. the femoral vein in the leg). These clots can become unstable and cause fatal conditions such as pulmonary embolism (PE) [Esmon, Blood Rev., 23, 2009; Bovill et al., Annu. Rev. Physiol., 73, 2011]. At the moment, the need for a prediction tool is widely recognised. With this project, we aim to investigate and understand the predictors of DVT based on a novel closer-to-reality in-vitro and in silico model developed by reproducing the anatomy of animal models in order to reduce their unnecessary use. We have already developed computational simulations [Ariane et al., Comput. Biol. Med., 89, 2017; Ariane et al., Comput. Fluids, 166, 2018] and experimental microfluidic models [Schofield et al., Commun. Mater., 1, 2020] of flow disturbances around valves of the veins. Here, we will develop advanced microfluidic in-vitro models, in which endothelial cells will be grown to mimic blood vessels and flexible valves without the need of sacrificing animals. We will then study the influence of blood flow characteristics on thrombus development Additionally, we will develop computational simulations. In the in-silico model we will be able to finely tune the three-dimensional geometry of the vein and valves, and to independently quantify the relative influence of each parameter on the insurgence of DVT. This novel approach will clarify the role of pathological blood flow in thrombosis initiation and propagation, and identify new factors predisposing to DVT. This will allow a personalized approach to identification and prophylaxis of people at major risk. We will then be able to follow the thrombus formation process and analyse the anatomical characteristics increasing thrombosis incidence. This is particular important as current protocols based on in-vivo studies failed to identify this. Moreover, this approach requires the use of thousands of animals worldwide that can be saved by implementing our approach. Eligibility requirements: The projects are intrinsically multi-disciplinary and thus will require the candidate to be highly motivated and interested in learning a wide range of scientifically challenging topics including microfluidics, cell biology, computational fluid dynamics, soft matter and biotechnology. Previous experience with microfluidics, optical microscope, cell culture and computational fluid dynamics will be highly appreciated. Applicants should have a Bioengineering, Chemical Engineering, Biophysics or Chemistry degree. International applicants should hold an IELTS English Score of 6.5 with no less than 6 in any band. Candidates with publications in peer-reviewed international scientific journals will be preferred. Contact information: E-mail: daniele.vigolo@sydney.edu.au Websites: danielevigolo.com/ https://www.sydney.edu.au/engine ... daniele-vigolo.html |
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