中国科学院上海巴斯德研究所是由中国科学院和法国巴斯德研究所共建的国际化研究机构,聚焦重大传染病的病原致病机制、免疫保护与病理规律等关键科学问题,开展基础与转化型研究,服务全球公共健康。上海巴斯德研究所具有完善的病原生物学、免疫学、疫苗学学科布局,拥有先进的科研装备与设施,是活跃在全球传染病防控领域的一支重要力量,是国际高端人才引进、一带一路科技合作与人才培养的重要基地和窗口。
因科研事业发展需要,微生物与宿主相互作用研究组面向国内外公开招聘博士后1名。
一、 研究方向
The gut microbiota seems to play a crucial role in maintaining host physiology by integrating signals from environmental factors such as diet, xenobiotics, temperature, stress and host-intrinsic cues like ageing. Undesirable changes in the gut microbiota composition (dysbiosis), while responding to innate or environmental stressors have been implicated as a critical determinant in the development of various modern diseases. Our prime interest at the Kundu Lab is to understand the evolving gut microbiota-host relations during distinct milestones across the lifespan of a host with special focus on intestinal epithelium that serves as a platform mediating this crosstalk. In particular, we study the influence of symbiotic or dysbiotic microbial signatures on intestinal stem cells, which maintain the epithelial dynamics and functions of the gut. Our goal is to decipher the molecular mechanisms through which gut microbiota influences key intestinal stem cell signaling pathways and functions during homeostasis or dysbiosis across host age. We are using state-of-the-art systems biology tools such as metagenomics and metabolomics, coupled with hypothesis-driven research in gnotobiotic animal models and human cohorts to elucidate the mechanistic aspects of microbiota-host communications. Our ultimate objective is to develop novel innovative therapeutic interventions targeting the gut microbiota against ageing associated human diseases such as cancer.
二、 岗位:博士后(2020Parag Kundu组)
三、 岗位职责:
The selected candidate will use high throughput sequencing to identify age associated microbial signatures. The candidate is expected to study microbial influence on stem cells using microbiota transplantation in transgenic germ-free mice and ex vivo platforms such as neurospheres and intestinal organoids. Our unit encourages hypothesis driven interdisciplinary research involving animal models, omics and cellular signaling.
1、 使用高通量测序来鉴定不同年龄宿主的微生物学特征;
2、 通过转基因无菌小鼠和离体实验平台(如神经球和肠道类器官)中的微生物群移植技术来研究微生物对宿主干细胞的影响;
3、 鼓励涉及动物模型、组学和细胞信号传导的以假设为驱动的跨领域研究。
四、 任职条件
- Applicants should have a PhD degree in stem cell biology and/or gut microbiota studies.
- Knowledge in stem cell biology, host microbe interactions and high throughput sequencing techniques are highly welcome, but not mandatory.
- Experience in intestinal organoid or neurosphere culture are welcome.
- Applicants must be highly motivated, talented and have a broad technical expertise.
- Applicants should be proficient in English communication skills and willing to work as a team.
1、 -具有干细胞生物学和/或肠道菌群研究背景的博士学位;
2、 -希望拥有干细胞生物学、宿主微生物相互作用和高通量测序技术,但不强制要求;
3、 -有肠道器官或神经球培养经验的更佳;
4、 -申请者必须具有高度的积极性、才华和广泛的技术专长;
5、 -申请人应精通英语沟通技巧,并愿意接受团队合作。
五、应聘方式:
请将所有应聘材料通过电子邮件发至slxing@ips.ac.cn,邮件主题请注明应聘岗位及编号。
1.英文个人简历
2.学历学位证书、身份证
本岗位自发布招聘启事之日起截至招满为止。初审合格后,将通知面试,择优录用,按中国科学院和上海市的标准提供有竞争力的薪酬待遇。 |