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Dear xx,
Thank you for submitting your manuscript to be considered for publication in xx and I hope that you and your family are staying healthy in this time. This decision was a tough one, as the referees, who are experts in XX, XX, and XX, and are generally big supporters of your work, are split and have serious reservations about the submission in its current form. Based on the attached reviewers¡¯ comments and my own reading of the work, I regret to inform you that we are unable to accept your manuscript for publication and are offering transfer to XX, another top journal in our field.
The translational aspects of the work were questioned by both referees, with even the positive referee requesting additional animal experiments whereas the negative referee did not evaluate the results as having sufficient selectivity for potential therapeutic intervention. Moreover, they questioned a well-defined mechanism of action relative to your previous work (Ö¸µÄÊǶ¾ÐÔÎÊÌ⣬»¹ÊÇÓ¦ÓÃÐÔ±»ÖÊÒÉ£©. I think this is an interesting chemical biology story, but at xx£¬ we are limited to publishing 200 papers a year and have to cover all fields in that limited number, so each study has to garner a high bar of enthusiasm with external referees. For context, each editor is only accepting 2-3 submissions per month and we receive new submissions daily.
At xx we aim to cover the most significant findings, both in terms of novelty and broad relevance, spanning all areas. As fellow academics, we are cognizant of the time and effort to review and revise manuscripts, so papers that are unlikely to pass this high bar, although they may be of good quality, must be turned away. For this reason, xx will likely reject a high proportion of articles submitted. This decision is not a judgment of the quality of the data or scholarship of the work, but merely reflects our desire to publish only the most influential research and allied fields. Although we regret that a positive recommendation cannot be made in this instance, we do welcome your future submissions to and support of XX.
However, xx is pleased to provide an opportunity to submit your manuscript to xx. The editors at xx encourage you to consider the recommendations received from xx. To have your manuscript files and information copied to a new submission for xx, please see the information below. The editors will evaluate your revised manuscript from a fresh perspective. Please note that submitting your manuscript to the xx does not guarantee acceptance.
Thank you again for your interest in xx. Again, I'm sorry that this current submission wasn't a good match for the journal, but I hope that you can see we give each manuscript serious consideration and try to give transparent feedback on how a decision is made and that you'll consider xx again in the future. We are also happy to receive presubmission inquiries as well. |