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澳大利亚麦考瑞大学生物医学科学学院Marco Morsch课题组招聘博士生、博士后
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澳大利亚麦考瑞大学
薪金:
面议

研究课题:用于了解脑部癌症生长和侵袭分子机理基础的神经胶质瘤斑马鱼模型研究

Recruitment:PhD Candidate and Post doctoral fellow
A glioblastoma zebrafish model to understand the molecular mechanisms underpinning the growth and invasiveness of brain cancers

Introduction
Glioblastoma multiforme is the most common and deadliest form of brain cancer and is highly resistant to therapeutic strategies. Glioblastomas are known to contain a high number of microglia/macrophages. This microglial/macrophage invasion supports tumour growth and the infiltration of surrounding brain tissue by glioma cells. Importantly, the presence of macrophages/microglia positively correlates with glioma grade and prognosis. However, the exact nature of microglia/macrophage-glioma interactions is not well understood but our experimental design provides a unique opportunity to study the cellular and molecular mechanisms that promote malignant glioma growth.
In this project we will establish the first zebrafish model in Australia to study glioblastoma growth and invasiveness in real-time in the living brain. Our team has established a collaboration with the University of Edinburgh to study microglia-brain tumour cell interactions in vivo in the larval zebrafish brain. We will be using state-of-the-art fluorescent labelling and visualisation techniques that allow us to track tumour progression and the impact of microglia to regulate that process. Targeting these microglia interactions may provide future therapeutic interventions to delay or even halt the progression of the tumour. In addition, our experimental system will provide unique insights into how microglia precursors may be used as a non-invasive route of access to the brain.

Hypothesis
Microglia and macrophages that have colonised the glioblastoma display pro-tumoral characteristics and interfering with the activation profile of these cells may delay tumour progression.

Aims
Aim 1: Investigate how host zebrafish microglia respond to the transplantation of human glioblastoma cells into the zebrafish brain.
Aim 2: Assess how microglia interference can affect tumour growth and invasiveness in vivo.
Aim 3: Test if microglia infiltration can be utilised to deliver therapeutic cargo (payload) directly to the tumour cells.

Outcome
We will establish the first glioblastoma model in zebrafish in Australia to test how microglia interact with human brain cancer cell lines. We hypothesize that manipulating microglia-tumour interactions will affect tumour progression. Understanding microglia-glioblastoma interactions will provide important insights into glioblastoma pathogenesis.

Contact and consult
Marco Morsch <marco.morsch@mq.edu.au>

Details about Dr. Marco Morsch: https://researchers.mq.edu.au/en/persons/marco-morsch

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