如题,招收CSC博士一名。
去年在小木虫看到的招生信息来到了荷兰,成了老板和目前科室第一个也暂时是唯一的中国学生。
现在是感恩回馈季。
你将会由我小老板和Human genetics的一个大老板共同指导。
大老板不熟悉,小老板是个特别nice,有能力&有耐心,很年轻的荷兰人。
同时莱顿是个很适合生活的大学镇。
感兴趣的同学快来联系吧。
LUMC邮箱有时候会把邮件当做垃圾邮件,如果你的邮件被blocked掉了,可以在帖子下面留言。
PHD PROJECT PROPOSAL:
Additional insights in the pathophysiology of type 2 diabetes mellitus using genetic interaction models.
Type 2 diabetes mellitus is a common age-related disease which prevalence is expected to further increase in the coming years. Studies in the pathophysiological mechanisms found that the risk of developing type 2 diabetes mellitus is associated with inherited and environmental factors. To date, over 200 genetic risk factors have been described for type 2 diabetes mellitus (Mahajan et al, 2018), but with little insight in their function in the pathophysiology. Despite multiple large efforts, the exact function of main genes associated with type 2 diabetes mellitus (e.g., TCF7L2) is also yet to be elucidated. Furthermore, as with multiple complex disease, the interactions between genetic and environmental factors (e.g., smoking, sleep, physical activity, nutritional intake) is poorly understood, although such findings could be of clinical relevance. With the increased public availability of large biobanks (e.g., UK Biobank and Million Veteran Program) and large collaborations (e.g., CHARGE, DIAGRAM), studies on gene-gene and gene-environment interactions will become increasingly popular to further characterize the genetic architecture of type 2 diabetes mellitus.
Main aims of the PhD project:
- Identify the gene networks affiliated with type 2 diabetes mellitus around main candidate genes using gene-gene interactions.
- Identify interactions of different pathways, resembling different pathophysiological mechanisms of type 2 diabetes mellitus, in relation to type 2 diabetes mellitus.
- Identify novel genetic variants associated with type 2 diabetes mellitus using gene-environment interactions.
This project is of specific interest for MSc students in the following fields:
Epidemiology, human/population genetics, genetic epidemiology, bioinformatics
Supervision:
- Professor Ko Willems van Dijk, department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands
- Dr. Raymond Noordam, department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands
Contact: dr. Raymond Noordam, r.noordam@lumc.nl |