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The resource of plants for Chinese medicine were abundant in yunnan province, and these medicinal plants existed many kinds of endophytes, which have the coevolution with hosts. And the bioactive constituents of host plants may induce the metabolism of endophytes. Many novel bioactive compounds might be found from it in adaptive culture condition, which have important value to the biopesticide and pharmaceutical research. Four endophytic microbes from two commonly used traditional Chinese medicine (TCM), Panax notoginseng and Paris polyphylla were induced by the bioactive compounds of TCM. The research of bioactive secondary metabolites from these induced endophytes will be carried out to find novel active compounds. This project was about the chemical mechanism of target compounds induced by the active ingredients of TCM. The active compounds from non-induction endophytes were also investigated, and the biological active compounds of host plants were also biotransformed by the endophytes. The relationship of the TCM active material and its endophytes will be investigated by the change mechanism of these active isolated metabolites. The biological activity and its material basis of the induced microbes will be also studied. 10-15 new compounds including of 1-2 unprecedented skeleton compounds and 1-2 bioactive constituents will be found through this project. The productions of bioactive substances were induced by the interaction of the TCM ingredient and endophytes. 2-3 SCI papers will be published, and 1 patent will be applied for. |
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