投稿一篇文章，一审意见是大修，其中一位审稿人的意见如下：The authors describe the study as a retrospective observational study. However, the analysis of ＊＊＊ on days 3, 7 and 14 seems to suggest that the study was prospectively conducted. Or do the authors suggest that analysis of ＊＊＊ in patients with sepsis is a routine workup done at their Institute for all such patients? Seems very perplexing. The authors need to clarify.