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最近在看李根喜老师实验室的一篇文章,有个图不是很没明白想和大家交流交流!!~

As an essential component of the cell skeleton, integrin connects the framework of the cells to the extra-cellular matrix (ECM).
In the process of tumor invasion, as well as other tissue remodeling processes such as embryonic development, the expression and activity of integrin are frequently regulated to direct and facilitate cell migration.
In a range of cancers, it has been reported that integrin overexpression is connected with tumor invasiveness and integrin may serve as a biomarker of malignant transformation.
Here, employing the above designed peptamer and the developed biosensing method, integrin abundance in several clinical samples of thyroid carcinoma is assayed, with the results being grouped, respectively, according to the T (tumor), N (node), and M (distant metastasis) stages of the cases examined (Figure 4).
Under the grouping based on T stage and M stage, the samples show no evident connection with the advancing of cancer (Figure 4a,c), but the expression seems to be, to some extent, correlated with N stage, or the situation of lymphnode metastasis (Figure 4b).
This can be explained considering the biological function of integrin in regulating cell connection withECM.
As a matter of fact,breaking through the tissue barriers such as the ECM and the basal membrane is the necessary step of tumor filtration and metastasis.
In this process, the up-regulation of integrin can indicate a frequent reconfiguration of cellular connection with the ECM, so integrin overexpression can usually be detected on the front edge of invasion, as well as sites of early metastasis located closely to the primary tumor, such as the sentinel lymph nodes.

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用户评论

一开始我非常担心编校质量,因为我从未使用过专业的编校公司。抱着试一试的想法用了朋友向我推荐的专业君论文。 事实证明专业君论文做得很出色!
除了编辑精准的表达和规范专业术语之外,我更欣赏专业君论文高度的敬业精神。
非常吃惊编辑居然为我做了三次免费修改,完全出乎我的意料。
受益于专业君论文 的仔细修订,我的文章最终被Experimental Brain Research接收。虽然影响因子不高,但非常高兴第一次被SCI期刊接收。

别沉了,看不懂这个图,但明天就要就讲了文献汇报了!!!!!