小木虫 --- 600万学术达人喜爱的学术科研平台

首页 >> 分析 >>查看话题

最近在看李根喜老师实验室的一篇文章,有个图不是很没明白想和大家交流交流!!~

As an essential component of the cell skeleton, integrin connects the framework of the cells to the extra-cellular matrix (ECM).
In the process of tumor invasion, as well as other tissue remodeling processes such as embryonic development, the expression and activity of integrin are frequently regulated to direct and facilitate cell migration.
In a range of cancers, it has been reported that integrin overexpression is connected with tumor invasiveness and integrin may serve as a biomarker of malignant transformation.
Here, employing the above designed peptamer and the developed biosensing method, integrin abundance in several clinical samples of thyroid carcinoma is assayed, with the results being grouped, respectively, according to the T (tumor), N (node), and M (distant metastasis) stages of the cases examined (Figure 4).
Under the grouping based on T stage and M stage, the samples show no evident connection with the advancing of cancer (Figure 4a,c), but the expression seems to be, to some extent, correlated with N stage, or the situation of lymphnode metastasis (Figure 4b).
This can be explained considering the biological function of integrin in regulating cell connection withECM.
As a matter of fact,breaking through the tissue barriers such as the ECM and the basal membrane is the necessary step of tumor filtration and metastasis.
In this process, the up-regulation of integrin can indicate a frequent reconfiguration of cellular connection with the ECM, so integrin overexpression can usually be detected on the front edge of invasion, as well as sites of early metastasis located closely to the primary tumor, such as the sentinel lymph nodes.

ac-2015-04423q_0004.gif

用户评论

别沉了,看不懂这个图,但明天就要就讲了文献汇报了!!!!!

不过,想要得到更加专业的回答,我建议还是下载小木虫APP。不要怕麻烦,APP里面有很多非常专业的资料,还有很多各专业的大牛免费解答各种问题,现在安装,下载资源还免费呢,赶快下载【小木虫APP】试试吧!


小木虫APP

学术科研必备,90%的学术科研者都在使用

关于最近在看李根喜老师实验室的一篇文章,有个图不是很没明白想和大家交流交流!!~的相关话题在小木虫APP已经有4位虫友给出了详细回复。

下载小木虫APP, 立即查看学术达人回复

赶快下载小木虫APP查看回复吧!

学术必备
与600万学术达人在线互动!


扫描下载送金币