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Pharmaceutical Emulsions-A Drug Developer’s Toolbag

作者 1949stone
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Pharmaceutical Emulsions-A Drug Developer’s Toolbag


The primary target audience for this text is students engaged in MPharm and
professional practice modules, pharmacy technician or internal formulation and
NPD courses and MScs in industrial pharmacy, PGDip industrial pharmaceutical
studies and related themes. Most schools of pharmacy have about 40–160
of these students per cohort. Yet the book must simultaneously be pertinent to
MRess, MScs, PhDs and postdocs (and BScs) in ‘pharmaceutical’ sciences. It
is thus specialist yet generalist, to the point of not simply being a collection of
research papers, but instead a teaching/training text. In light of this, the book
is not targeted exclusively at either the undergraduate, the advanced researcher
or the experienced industrialist. It will be seen by industrial pharmacists (pharmaceutical
scientists, chemists, engineers, etc) as generalist, and for real subject
experts it merely represents a referential ‘pocket guide’ and not an encyclopaedic
reference manual. Unlike many colloid and dispersions books, this text is not
generalist in the sense of application universality and it is exclusively written
for those involved with pharmaceutical emulsions (a ‘hot’ topic, to quote one
reviewer). In this sense, it has absolute value and novelty in terms of being rather
specific. Many other books are available which elaborate theory and physics or
physical chemistry background (e.g. Adamson, 1990; Hiemenz and Rajagopalan,
1997; Goodwin, 2000 and more recent editions). In principle, this book is primarily
targeted at pharmacists, pharmaceuticists, medics and pharmacologists, and its
form alludes to this in a significant manner.
I started my involvement with ‘colloids’ (now ‘nanotechnology’ in current
‘in-speak’) as an undergraduate dealing with industrial dispersions, then as a masters’
chemical engineering student dealing with fabrication. During a physics PhD
and numerous postdocs I had the pleasure to work with and in research groups in
the UK, France, Germany and Italy, where dispersions (foams, thin liquid films and
emulsions) were the mainstay of the target product or the vehicle for mechanistic
elucidation. Dispersions investigated included model food foams and emulsions,
liquid ion-exchange systems, theoretical and mechanistic models and industrial
products of a food, automotive, petrochemical and medicinal nature. I have had
the great luck to have worked and collaborated with some truly great thinkers
and international colloid celebrities: Peter Wilde, David Clark, Jim Mingins, Vic
Morris, Brian Robinson, Eric Dickinson, Monique Axelos, Yves Popineau, Daniel
Bonn, Jacques Meunier, Vance Bergeron, Zdravko Lalchev, Reinhard Miller,
J¨urgen Kr¨agel, Clive Washington, Seyed Moghimi, Vladimir Torchilin and Sandy
Florence, to name but a few. Today, and for the last decade or more, most of
my interest has been in pharmaceutical dispersions. Coarse emulsions (hereafter
simply referred to as ‘emulsions’), nanoemulsions, micelles – simple, reverse and
swollen – are the building blocks and centre points of nanomedicine, the pharmaceutical
and therapeutic environment and modelling of drug encapsulation, new
product design (nanoparticle drug delivery systems), increased efficacy and dosage
miniaturisation, interfacial sculpting and molecular nanoengineering.
My research expertise, on which this book is founded, traverses areas of biophysics,
material sciences, pharmaceutics and biopharmaceutics, food science,
chemical engineering, physical chemistry, rheology and polymer science, medicinal
chemistry, chemical biology, engineering, industrial product design and regulation
and analytical chemistry. For teaching, I use a wide variety of books or
chapters, and there are a number of really good pharmaceutics textbooks, but their
main failings for pharmacy students is that they traverse year one to year four basic
concepts such as pKa and log D and feature only one chapter (generalist) dealing
with the pivotal role of ‘emulsions’ in medical products (therapeutics) sciences.
I hope to expand on this information without providing a cost-restrictive or excessively
detailed text and to focus entirely upon the dispersed particle or particle
within matrix technologies, which is perhaps better suited for students with some
basic primary experience or knowledge of pharmacy dispersions. Using many
figures and tables is the chosen, I have attempted to provide a summary of the
salient facts and thus keep the text short. As with all things, there is a compromise
to be made between what we know and would like to say and the restrictions of
time and the funds available in the student’s pocket. I hope students and professionals
alike will find the book useful, suitably informative and yet portable and
readable.
Dipak K. Sarker
Brighton, 2013

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